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Structural biology

DNA search and rescue

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How do DNA-repair enzymes find aberrant nucleotides among the myriad of normal ones? One enzyme has been caught in the act of checking for damage, providing clues to its quality-control process.

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Figure 1: Damage detection — how hOGG1 searches for damaged guanine residues (oxoG, or oG), based on the findings of Banerjee and colleagues1.

References

  1. Banerjee, A., Yang, W., Karplus, M. & Verdine, G. L. Nature 434, 612–618 (2005).

    Article  ADS  CAS  Google Scholar 

  2. Schärer, O. D. Angew. Chem. Int. Edn Engl. 42, 2946–2974 (2003).

    Article  Google Scholar 

  3. Barnes, D. E. & Lindahl, T. Annu. Rev. Genet. 38, 445–476 (2004).

    Article  CAS  Google Scholar 

  4. David, S. S. & Williams, S. D. Chem. Rev. 98, 1221–1261 (1998).

    Article  CAS  Google Scholar 

  5. Al-Tassan, N. et al. Nature Genet. 30, 227–232 (2002).

    Article  CAS  Google Scholar 

  6. Micheals, M. L. & Miller, J. H. J. Bacteriol. 174, 6321–6325 (1992).

    Article  Google Scholar 

  7. Fromme, J. C., Banerjee, A. & Verdine, G. L. Curr. Opin. Struct. Biol. 14, 43–49 (2004).

    Article  CAS  Google Scholar 

  8. Stivers, J. T. Prog. Nucleic Acid Res. Mol. Biol. 77, 37–65 (2004).

    Article  CAS  Google Scholar 

  9. Parikh, S. S., Putnam, C. & Tainer, J. A. Mutat. Res. 30, 183–199 (2000).

    Article  Google Scholar 

  10. Bruner, S. D., Norman, D. P. G. & Verdine, G. L. Nature 403, 859–866 (2000).

    Article  ADS  CAS  Google Scholar 

  11. Huang, H., Chopra, R., Verdine, G. L. & Harrison, S. C. Science 282, 1669–1675 (1998).

    Article  ADS  CAS  Google Scholar 

  12. Jiang, Y. L. et al. Biochemistry 43, 15429–15438 (2004).

    Article  CAS  Google Scholar 

Download references

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  1. the Department of Chemistry, University of Utah, 315 South 1400 East, Salt Lake City, 84112, Utah, USA

    Sheila S. David

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  1. Sheila S. David
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David, S. DNA search and rescue. Nature 434, 569–570 (2005). https://doi.org/10.1038/434569a

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