Skip to main content
SpringerLink
Log in

Physiology

Do neural signals remodel bone?

  • News & Views
  • Published:

From Nature

View current issue Submit your manuscript

The hormone leptin is best known for its influence on body weight. But it also controls bone mass, and recent work in mice is beginning to uncover the neuroendocrine systems involved.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Brain and bone in sympathy.

References

  1. Ahima, R. S., Saper, C. B., Flier, J. S. & Elmquist, J. K. Front. Neuroendocrinol. 21, 263–307 (2000).

    Article  CAS  Google Scholar 

  2. Friedman, J. M. Nutr. Rev. 60, S1–S14 (2002).

    Article  Google Scholar 

  3. Flier, J. S. Cell 116, 337–350 (2004).

    Article  CAS  Google Scholar 

  4. Zigman, J. M. & Elmquist, J. K. Endocrinology 144, 3749–3756 (2003).

    Article  CAS  Google Scholar 

  5. Takeda, S. et al. Cell 111, 305–317 (2002).

    Article  CAS  Google Scholar 

  6. Ducy, P. et al. Cell 100, 197–207 (2000).

    Article  CAS  Google Scholar 

  7. Elefteriou, F. et al. Nature 434, 514–520 (2005).

    Article  ADS  CAS  Google Scholar 

  8. Burt-Pichat, B. et al. Endocrinology 146, 503–510 (2005).

    Article  CAS  Google Scholar 

  9. Pasco, J. A. et al. J. Bone Miner. Res. 19, 19–24 (2004).

    Article  CAS  Google Scholar 

  10. Rejnmark, L. et al. Calcif. Tissue Int. 75, 365–372 (2004).

    Article  CAS  Google Scholar 

  11. Schlienger, R. G., Kraenzlin, M. E., Jick, S. S. & Meier, C. R. J. Am. Med. Assoc. 292, 1326–1332 (2004).

    Article  CAS  Google Scholar 

  12. Kristensen, P. et al. Nature 393, 72–76 (1998).

    Article  ADS  CAS  Google Scholar 

  13. Elias, C. F. et al. Neuron 21, 1375–1385 (1998).

    Article  CAS  Google Scholar 

  14. Balthasar, N. et al. Neuron 42, 983–991 (2004).

    Article  CAS  Google Scholar 

  15. Elias, C. F. et al. J. Comp. Neurol. 432, 1–19 (2001).

    Article  CAS  Google Scholar 

  16. Reseland, J. E. & Gordeladze, J. O. FEBS Lett. 528, 40–42 (2002).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, 02215, Massachusetts, USA

    Joel K. Elmquist & Gordon J. Strewler

Authors
  1. Joel K. Elmquist
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Gordon J. Strewler
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Elmquist, J., Strewler, G. Do neural signals remodel bone?. Nature 434, 447–448 (2005). https://doi.org/10.1038/434447a

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/434447a

  • Springer Nature Limited

This article is cited by

Search

Navigation