Skip to main content
Log in

Medicine

A cholesterol connection in RNAi

  • News & Views
  • Published:

From Nature

View current issue Submit your manuscript

RNA interference — RNAi for short — might provide a way to silence disease-associated genes, but problems of delivery have hampered progress. Those problems may have been solved, at least in animal studies.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Figure 1: Silencing genes the RNAi way.

References

  1. Soutschek, J. et al. 432, 173–178 (2004).

  2. Novina, C. D. & Sharp, P. A. Nature 430, 161–164 (2004).

    Article  ADS  CAS  Google Scholar 

  3. Mello, C. C. & Conte, D. Jr Nature 431, 338–342 (2004).

    Article  ADS  CAS  Google Scholar 

  4. Hannon, G. J. & Rossi, J. J. Nature 431, 371–378 (2004).

    Article  ADS  CAS  Google Scholar 

  5. Tuschl, T. & Borkhardt, A. Mol. Interv. 2, 158–167 (2002).

    Article  CAS  Google Scholar 

  6. Zamecnik, P. C. & Stephenson, M. L. Proc. Natl Acad. Sci. USA 75, 280–284 (1978).

    Article  ADS  CAS  Google Scholar 

  7. Fire, A. et al. Nature 391, 806–811 (1998).

    Article  ADS  CAS  Google Scholar 

  8. Elbashir, S. M. et al. Nature 411, 494–498 (2001).

    Article  ADS  CAS  Google Scholar 

  9. Elbashir, S. M., Lendeckel, W. & Tuschl, T. Genes Dev. 15, 188–200 (2001).

    Article  CAS  Google Scholar 

  10. Caplen, N. J., Parrish, S., Imani, F., Fire, A. & Morgan, R. A. Proc. Natl Acad. Sci. USA 98, 9742–9747 (2001).

    Article  ADS  CAS  Google Scholar 

  11. Schwarz, D. S., Tomari, Y. & Zamore, P. D. Curr. Biol. 14, 787–791 (2004).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Rossi, J. A cholesterol connection in RNAi. Nature 432, 155–156 (2004). https://doi.org/10.1038/432155a

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/432155a

  • Springer Nature Limited

This article is cited by

Navigation