Skip to main content
Log in

Antibiotics at the crossroads

  • Commentary
  • Published:

From Nature

View current issue Submit your manuscript

Are we making the right choices to bring new drugs to the marketplace?

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Projan, S. J. Curr. Opin. Microbiol. 6, 427–430 (2003).

    Article  Google Scholar 

  2. Wenzel, R. P. N. Engl. J. Med. 351, 523–526 (2004).

    Article  CAS  Google Scholar 

  3. Infectious Diseases Society of America. Bad Bugs, No Drugs; http://www.idsociety.org/Template.cfm?Section=Home&CONTENTID=7455&TEMPLATE=/ContentManagement/ContentDisplay.cfm (2004).

  4. Centers for Disease Control and Prevention. A Public Health Action Plan to Combat Antimicrobial Resistance; http://www.cdc.gov/drugresistance/actionplan/html/index.htm (2000).

  5. Coates, A., Hu, Y., Bax, R. & Page, C. Nature Rev. Drug Discov. 1, 895–910 (2002).

    Article  CAS  Google Scholar 

  6. World Health Organization Draft Global Strategy for the Containment of Antimicrobial Resistance; http://www.who.int/emc/amr.html (2001).

  7. Service, R. F. Science 303, 1796–1799 (2004).

    Article  Google Scholar 

  8. Walsh, C. Nature Rev. Microbiol. 1, 65–70 (2003).

    Article  CAS  Google Scholar 

  9. Miesel, L., Greene, J. & Black, T. A. Nature Rev. Genet. 4, 442–456 (2003).

    Article  CAS  Google Scholar 

  10. Global Alliance for Tuberculosis Drug Development. The Economics of TB Drug Development; http://www.tballiance.org/pdf/Economics%20Report%20Full%20(final).pdf (2001).

  11. Chopra, I., Hodgson, J., Metcalf, B. & Poste, G. J. Am. Med. Assoc. 275, 401–403 (1996).

    Article  CAS  Google Scholar 

  12. Darwin, K. H., Ehrt, S., Gutierrez-Ramos, J. C., Weich, N. & Nathan, C. F. Science 302, 1963–1966 (2003).

    Article  ADS  CAS  Google Scholar 

  13. Bryk, R., Lima, C. D., Erdjument-Bromage, H., Tempst, P. & Nathan, C. Science 295, 1073–1077 (2002).

    Article  ADS  CAS  Google Scholar 

  14. Schnappinger, D. et al. J. Exp. Med. 198, 693–704 (2003).

    Article  CAS  Google Scholar 

  15. Sassetti, C. M., Boyd, D. H. & Rubin, E. J. Mol. Microbiol. 48, 77–84 (2003).

    Article  CAS  Google Scholar 

  16. Tong, A. H. et al. Science 303, 808–813 (2004).

    Article  ADS  CAS  Google Scholar 

  17. Fidock, D. A., Rosenthal, P. J., Croft, S. L., Brun, R. & Nwaka, S. Nature Rev. Drug Discov. 3, 509–520 (2004).

    Article  CAS  Google Scholar 

  18. Manetsch, R. et al. J. Amer. Chem. Soc. 126, 12809–12819(2004).

    Article  CAS  Google Scholar 

  19. Keller, M. & Zengler, K. Nature Rev. Microbiol. 2, 141–150 (2004).

    Article  CAS  Google Scholar 

  20. Liu, J. et al. Nature Biotechnol. 22, 185–191 (2004).

    Article  CAS  Google Scholar 

  21. Nwaka, S. & Ridley, R. G. Nature Rev. Drug Discov. 2, 919–928 (2003).

    Article  CAS  Google Scholar 

  22. Vennerstrom, J. L. et al. Nature 430, 900–904 (2004).

    Article  ADS  CAS  Google Scholar 

  23. World Health Organization, Commisssion on Macroeconomics and Health Macroeconomics and Health: Investing in Health for Economic Development; http://www.cmhealth.org (2001).

Download references

Acknowledgements

Thanks to A. Apt, K. Deitsch, H. Djaballah, B. Ganem, W. Jorgensen, T. Kapoor, M. MacCoss, V. Mizrahi, S. Projan, L. Quadri, K. Rhee, M. Rosenberg, D. Russell, D. Scheinberg, D. Schnappinger, D. Tan, T. Templeton and P. van Helden for stimulating discussions. Special thanks are due to P. Davies, S. Ehrt, M. Glickman, B. Kelly, J. McKinney and S. Nwaka.

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Nathan, C. Antibiotics at the crossroads. Nature 431, 899–902 (2004). https://doi.org/10.1038/431899a

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/431899a

  • Springer Nature Limited

This article is cited by

Navigation