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An inflammatory link

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The NF-κB protein is a key player in inflammation. It now seems that it might also activate signalling pathways, in both cancer cells and tumour-associated inflammatory cells, that promote malignancy.

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Figure 1: Opposing effects of the NF-κB protein in normal tissues and in cancer.

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Authors and Affiliations

  1. Cancer Research UK Translational Oncology Laboratory, Barts and The London Queen Mary's Medical School, Charterhouse Square, London, EC1M 6BQ, UK

    Fran Balkwill

  2. frances.balkwill@cancer.org.uk,

    Fran Balkwill

  3. the Department of Pathology and Comprehensive Cancer Centre, Cancer Research Institute, University of California at San Francisco, 2340 Sutter Street, San Francisco, 94143, California, USA

    Lisa M. Coussens

Authors
  1. Fran Balkwill
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  2. Lisa M. Coussens
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Balkwill, F., Coussens, L. An inflammatory link. Nature 431, 405–406 (2004). https://doi.org/10.1038/431405a

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