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Cell biology

Barbed ends rule

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To explore their surroundings, cells use probes of various shapes. Whether the probes are broad and flat, or long and thin, seems to be regulated by proteins at the growing ends of actin filaments.

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Figure 1: Model for how the growing ends of actin filaments regulate cellular protrusions.

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  1. the Departments of Biology and Cell Biology, University of Virginia, Charlottesville, 22903, Virginia, USA

    Dorothy A. Schafer

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  1. Dorothy A. Schafer
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Schafer, D. Barbed ends rule. Nature 430, 734–735 (2004). https://doi.org/10.1038/430734a

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