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Tightrope act

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A component of the ‘tip link’ that conveys tension to mechanically sensitive ion channels in the inner ear has been identified. The finding raises new questions about elastic elements in our hearing apparatus.

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Figure 1: Models for mechanotransduction in hair cells of the inner ear.
Figure 2: Structure of the tip link, and molecular models.

References

  1. Söllner, C. et al. Nature 428, 955–959 (2004).

    Article  ADS  Google Scholar 

  2. Siemens, J. et al. Nature 428, 950–955 (2004).

    Article  ADS  CAS  Google Scholar 

  3. Boeda, B. et al. EMBO J. 21, 6689–6699 (2002).

    Article  CAS  Google Scholar 

  4. Nicolson, T. et al. Neuron 20, 271–283 (1998).

    Article  CAS  Google Scholar 

  5. Zhao, Y., Yamoah, E. N. & Gillespie, P. G. Proc. Natl Acad. Sci. USA 93, 15469–15474 (1996).

    Article  ADS  CAS  Google Scholar 

  6. Goodyear, R. J. & Richardson, G. P. J. Neurosci. 23, 4878–4887 (2003).

    Article  CAS  Google Scholar 

  7. Howard, J. & Hudspeth, A. J. Neuron 1, 189–199 (1988).

    Article  CAS  Google Scholar 

  8. Kachar, B., Parakkal, M., Kurc, M., Zhao, Y. & Gillespie, P. G. Proc. Natl Acad. Sci. USA 97, 13336–13341 (2000).

    Article  ADS  CAS  Google Scholar 

  9. Zhu, B. et al. Biophys. J. 84, 4033–4042 (2003).

    Article  ADS  CAS  Google Scholar 

  10. Boggon, T. J. et al. Science 296, 1308–1313 (2002).

    Article  ADS  CAS  Google Scholar 

  11. Sidi, S., Friedrich, R. W. & Nicolson, T. Science 301, 96–99 (2003).

    Article  ADS  CAS  Google Scholar 

  12. Howard, J. & Bechstedt, S. Curr. Biol. 14, R224–R226 (2004).

    Article  CAS  Google Scholar 

  13. Michaely, P., Tomchick, D. R., Machius, M. & Anderson, R. G. EMBO J. 21, 6387–6396 (2002).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Howard Hughes Medical Institute and the Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, 02115, Massachusetts, USA

    David P. Corey

  2. Department of Physics and the Theoretical and Computational Biophysics Group, Beckman Institute, University of Illinois at Urbana-Champaign, 405 N Mathew, Urbana, 61801, Illinois, USA

    Marcos Sotomayor

Authors
  1. David P. Corey
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  2. Marcos Sotomayor
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Corey, D., Sotomayor, M. Tightrope act. Nature 428, 901–903 (2004). https://doi.org/10.1038/428901a

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