The diversity of cellular stresses that activate the 'guardian of the genome' — p53 — begs the question of how these signals all converge on one protein. Perhaps the key to this integration is the nucleolus.
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Horn, H., Vousden, K. Guarding the guardian?. Nature 427, 110–111 (2004). https://doi.org/10.1038/427110a
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DOI: https://doi.org/10.1038/427110a
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