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Taking apart a cancer protein

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Generation of a particular 'fusion' protein is characteristic of one type of leukaemia. But is it in fact the cleavage of this protein into smaller parts that is important? Provocative new findings suggest that it is.

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Figure 1: Hypothetical role of the PML–RARα fusion protein in acute promyelocytic leukaemia (APL).

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Authors and Affiliations

  1. Departments of Medicine and of Pathology, Molecular Biology Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, 10021, New York, USA

    Pier Paolo Scaglioni & Pier Paolo Pandolfi

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  1. Pier Paolo Scaglioni
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  2. Pier Paolo Pandolfi
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Correspondence to Pier Paolo Pandolfi.

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Paolo Scaglioni, P., Paolo Pandolfi, P. Taking apart a cancer protein. Nature 426, 512–513 (2003). https://doi.org/10.1038/426512a

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