The genetics of development can often explain the genesis of cancer. This now seems to be true for cancers of the gut, but the patterns of gene expression in these tumours tell a tale with a twist.
This is a preview of subscription content, log in via an institution to check access.
References
McMahon, A. P., Ingham, P. W. & Tabin, C. J. Curr. Top. Dev. Biol. 53, 1–114 (2003).
Taipale, J. & Beachy, P. A. Nature 411, 349–354 (2001).
Berman, D. M. et al. Nature 425, 846–851 (2003).
Thayer, S. P. et al. Nature 425, 851–856 (2003).
Hahn, H. et al. Cell 85, 841–851 (1996).
Johnson, R. L. et al. Science 272, 1668–1671 (1996).
Goodrich, L. V. et al. Science 277, 1109–1113 (1997).
Hahn, H. et al. Nature Med. 4, 619–622 (1998).
Xie, J. et al. Nature 391, 90–92 (1998).
Taipale, J. et al. Nature 406, 1005–1009 (2000).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Scott, M. A twist in a hedgehog's tale. Nature 425, 781–782 (2003). https://doi.org/10.1038/425780a
Issue Date:
DOI: https://doi.org/10.1038/425780a
- Springer Nature Limited
This article is cited by
-
Hedgehog pathway activation in human transitional cell carcinoma of the bladder
British Journal of Cancer (2012)