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Cardiovascular biology

Signalling silenced

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The mechanism by which the TIMP-2 protein inhibits blood-vessel formation has been uncovered — and it is not as expected. The finding has implications for treating a cancer by cutting off its blood supply.

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Figure 1: Blocking blood-vessel growth: how TIMP-2 does it.

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Authors and Affiliations

  1. Centre for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, University of Leuven, Leuven, B-3000, Belgium

    Edward M. Conway & Peter Carmeliet

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  1. Edward M. Conway
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  2. Peter Carmeliet
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Correspondence to Peter Carmeliet.

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Conway, E., Carmeliet, P. Signalling silenced. Nature 425, 139–140 (2003). https://doi.org/10.1038/425139a

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