An important category of genes — so-called pluripotency genes — are active in early embryos but silent in specialized cells. It seems that this silencing is difficult to reverse in cloned embryos.
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Reik, W., Dean, W. Silent clones speak up. Nature 423, 390–391 (2003). https://doi.org/10.1038/423390a
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DOI: https://doi.org/10.1038/423390a
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