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Stem cells

Self-renewal writ in blood

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The ability to self-renew is a defining property of stem cells, and a protein in blood stem cells that controls their self-renewal has been discovered. That same protein is also crucial for the development of leukaemia.

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Figure 1: The choices available to haematopoietic stem cells (HSCs) upon division.

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  1. the Division of Cell and Molecular Biology, and the Department of Molecular Genetics and Microbiology, University Health Network, University of Toronto, 620 University Avenue, Toronto, M5G 2C1, Ontario, Canada

    John E. Dick

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  1. John E. Dick
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Correspondence to John E. Dick.

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Dick, J. Self-renewal writ in blood. Nature 423, 231–232 (2003). https://doi.org/10.1038/423231a

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