Studies of the retinoblastoma gene can still deliver surprises, and enlightenment. Several of the abnormalities in mice lacking this gene are, it seems, the indirect consequence of a placental defect.
This is a preview of subscription content, log in via an institution to check access.
References
Wu, L. et al. Nature 421, 942–947 (2003).
Lee, E. Y.-H. P. et al. Nature 359, 288–294 (1992).
Jacks, T. et al. Nature 359, 295–300 (1992).
Clarke, A. R. et al. Nature 359, 328–330 (1992).
Rossant, J. & Cross, J. C. Nature Rev. Genet. 2, 538–548 (2001).
Williams, B. O. et al. EMBO J. 13, 4251–4259 (1994).
Maandag, E. C. et al. EMBO J. 13, 4260–4268 (1994).
Tsai, K. Y. et al. Mol. Cell 2, 293–304 (1998).
Ziebold, U., Reza, T., Caron, A. & Lees, J. A. Genes Dev. 15, 386–391 (2001).
Lasorella, A., Noseda, M., Beyna, M., Yokota, Y. & Iavarone, A. Nature 407, 592–598 (2000).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Dyson, N. A twist in a mouse tale. Nature 421, 903–904 (2003). https://doi.org/10.1038/421903a
Issue Date:
DOI: https://doi.org/10.1038/421903a
- Springer Nature Limited