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Toxicology rethinks its central belief

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Hormesis demands a reappraisal of the way risks are assessed.

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Figure 1: Hypothetical curves depicting (a) threshold, (b) linear non-threshold, and (c) hormetic dose-response models using cancer (number of tumours per animal) as the endpoint.

References

  1. Luckey, T. D. Radiation Hormesis (CRC Press, Boca Raton, 1991).

    Google Scholar 

  2. Stebbing, A. R. D. Mutat. Res. 403, 249–258 (1998).

    Article  CAS  Google Scholar 

  3. Calabrese, E. J. & Baldwin, L. A. Hum. Exper. Toxicol. 19, 2–31 (2000).

    Article  CAS  Google Scholar 

  4. Calabrese, E. J. & Baldwin, L. A. Toxicol. Sci. 71, 246–250 (2003).

    Article  CAS  Google Scholar 

  5. Calabrese, E. J. & Baldwin, L. A. (eds) Crit. Rev. Toxicol. 31, 349–669 (2001).

    Google Scholar 

  6. Callahan, B. G., Gaylor, D. & Stanek, E. J. (eds) Hum. Ecol. Risk Assess. 7, 779–942 (2001).

    Article  Google Scholar 

  7. Renn, O. Hum Exper. Toxicol. 17, 431–438 (1998).

    Article  CAS  Google Scholar 

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Acknowledgements

Our work is sponsored by the Air Force Office of Scientific Research. Our views do not necessarily represent those of the Air Force Office of Scientific Research or the US Government.

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  1. Department of Environmental Health Sciences, University of Massachusetts, Amherst, 01003, Massachusetts, USA

    Edward J Calabrese & Linda A Baldwin

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  1. Edward J Calabrese
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  2. Linda A Baldwin
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Calabrese, E., Baldwin, L. Toxicology rethinks its central belief. Nature 421, 691–692 (2003). https://doi.org/10.1038/421691a

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