Mice lacking a certain neurotransmitter receptor have trouble forgetting scary experiences. This finding uncovers a fear-regulating feedback loop in the brain that might be at work in humans, too.
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References
LeDoux, J. E. The Emotional Brain: The Mysterious Underpinning of Emotional Life (Simon & Schuster, New York, 1996).
Shumyatsky, G. P. et al. Cell 111, 905–918 (2002).
Aggleton, J. P. (ed.) The Amygdala: A Functional Analysis (Oxford Univ. Press, Oxford, 2000).
Cahill, L., Weinberger, N. M., Roozendaal, B. & McGaugh, J. L. Neuron 23, 227–228 (1999).
Maren, S., Aharonov, G., Stote, D. L. & Fanselow, M. S. Behav. Neurosci. 110, 1365–1374 (1996).
Lamprecht, R., Farb, C. R. & LeDoux, J. E. Neuron 36, 727–738 (2002).
Ressler, K. J., Paschall, G., Zhou, X. L. & Davis, M. J. Neurosci. 22, 7892–7902 (2002).
Rogan, M. T., Staubli, U. V. & LeDoux, J. E. Nature 390, 604–607 (1997).
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Dudai, Y. Fear thou not. Nature 421, 325–327 (2003). https://doi.org/10.1038/421325a
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DOI: https://doi.org/10.1038/421325a
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