Sodium-ion channels usually open in response to a voltage change across the membrane in which they sit. But, surprisingly, a growth factor secreted by neurons also rapidly triggers the opening of a specific sodium channel.
This is a preview of subscription content, log in via an institution to check access.
References
Blum, R., Kafitz, K. W. & Konnerth, A. Nature 419, 687–693 (2002).
Kafitz, K. W., Rose, C. R., Thoenen, H. & Konnerth, A. Nature 401, 918–921 (1999).
Bibel, M. & Barde, Y.-A Genes Dev. 14, 2929–2937 (2000).
Poo, M. M. Nature Rev. Neurosci. 2, 24–32 (2001).
Kovalchuk, Y., Hanse, E., Kafitz, K. W. & Konnerth, A. Science 295, 1729–1734 (2002).
Dib-Hajj, S., Black, J. A., Cummins, T. R. & Waxman, S. G. Trends Neurosci. 25, 253–259 (2002).
Benn, S. C., Costigan, M., Tate, S., Fitzgerald, M. & Woolf, C. J. Neurosci. 21, 6077–6085 (2001).
Apfel, S. C. Clin. J. Pain 16, 7–11 (2000).
Li, H.-S, Xu, S.-Z. S. & Montell, C. Neuron 24, 261–273 (1999).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Barde, YA. Neurotrophin channels excitement. Nature 419, 683–684 (2002). https://doi.org/10.1038/419683a
Issue Date:
DOI: https://doi.org/10.1038/419683a
- Springer Nature Limited