People with the genetic disease Peutz–Jeghers syndrome have many intestinal polyps — benign tissue outgrowths. These seldom become malignant, and the reason may lie in the properties of the affected gene.
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References
Bardeesy, N. et al. Nature 419, 162–167 (2002).
Haggitt, R. C. & Reid, B. J. Am. J. Surg. Pathol. 10, 871–887 (1986).
Kinzler, K. W. & Vogelstein, B. Science 280, 1036–1037 (1998).
Wang, Z. J. et al. J. Pathol. 188, 613–617 (1999).
Ylikorkala, A. et al. Science 293, 1323–1326 (2001).
Miyoshi, H. et al. Cancer Res. 62, 2261–2266 (2002).
Jishage, K. et al. Proc. Natl Acad. Sci. USA 99, 8903–8908 (2002).
Sherr, C. J. Nature Rev. Mol. Cell Biol. 2, 731–737 (2001).
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van der Weyden, L., Jonkers, J. & Bradley, A. Stuck at first base. Nature 419, 127–128 (2002). https://doi.org/10.1038/419127a
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DOI: https://doi.org/10.1038/419127a
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