Skip to main content

Advertisement

Log in

Amyloid diseases

Small drugs lead the attack

  • News & Views
  • Published:

From Nature

View current issue Submit your manuscript

Many human disorders — a well-known example being Alzheimer's disease — are characterized by the misfolding and aggregation of key proteins. New small-molecule drugs may help to destabilize these aggregates.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Figure 1: Structure of the pentamer of the serum amyloid P protein (SAP)13.

References

  1. Pepys, M. B. et al. Nature 417, 254–259 (2002).

    Article  ADS  CAS  PubMed  Google Scholar 

  2. Selkoe, D. J. Physiol. Rev. 81, 741–766 (2001).

    Article  CAS  PubMed  Google Scholar 

  3. Schenk, D. et al. Nature 400, 173–177 (1999).

    Article  ADS  CAS  PubMed  Google Scholar 

  4. SCRIP World Pharmaceut. News No 2726, 23 (2002).

  5. Bard, F. et al. Nature Med. 6, 916–919 (2000).

    Article  CAS  PubMed  Google Scholar 

  6. Findeis, M. A. Biochim. Biophys. Acta 1502, 76–84 (2000).

    Article  CAS  PubMed  Google Scholar 

  7. Soto, C., Saborio, G. P. & Permanne, B. Acta Neurol. Scand. 102 (Suppl. 176), 90–95 (2000).

    Article  Google Scholar 

  8. Cherny, R. A. et al. Neuron 30, 665–676 (2001).

    Article  CAS  PubMed  Google Scholar 

  9. Masters, C. in 7th Int. Geneva/Springfield Alzheimer's Symp. 4 April 2002.

  10. Garceau, D., Gurbindo, C. & Laurin, J. in 7th Int. Geneva/Springfield Alzheimer's Symp. 4 April 2002.

  11. Gervais, F. et al. in 7th Int. Geneva/Springfield Alzheimer's Symp. 4 April 2002.

  12. Hind, C. R., Collins, P. M., Caspi, D., Baltz, M. L. & Pepys, M. B. Lancet 324, 376–378 (1984).

    Article  Google Scholar 

  13. Emsley, J. et al. Nature 367, 338–345 (1994).

    Article  ADS  CAS  PubMed  Google Scholar 

  14. Korth, C. et al. Proc. Natl Acad. Sci. USA 98, 9836–9841 (2001).

    Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Leslie Iversen.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Iversen, L. Small drugs lead the attack. Nature 417, 231–233 (2002). https://doi.org/10.1038/417231a

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/417231a

  • Springer Nature Limited

Navigation