To understand cell signalling during development, we need to know how whole signalling networks — not just their individual components — are regulated. Two new studies highlight this point.
This is a preview of subscription content, log in via an institution to check access.
References
Tsang, M., Friesel, R., Kudoh, T. & Dawid, I. B. Nature Cell Biol. 4, 165–169 (2002).
Fürthauer, M., Lin, W., Ang, S. L., Thisse, B. & Thisse, C. Nature Cell Biol. 4, 170–174 (2002).
Fürthauer, M., Reifers, F., Brand, M., Thisse, B. & Thisse, C. Development 128, 2175–2186 (2001).
Raible, F. & Brand, M. Mech. Dev. 107, 105–117 (2001).
Niehrs, C. & Pollet, N. Nature 402, 483–487 (1999).
Onichtchouk, D. et al. Nature 401, 480–485 (1999).
Lamar, E. et al. Genes Dev. 15, 1885–1899 (2001).
Jen, W.-C, Gawantka, V., Pollet, N., Niehrs, C. & Kintner, C. Genes Dev. 13, 1486–1499 (1999).
Becskei, A. & Serrano, L. Nature 405, 590–593 (2000).
Elowitz, M. B. & Leibler, S. Nature 403, 335–338 (2000).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Niehrs, C., Meinhardt, H. Modular feedback. Nature 417, 35–36 (2002). https://doi.org/10.1038/417035a
Issue Date:
DOI: https://doi.org/10.1038/417035a
- Springer Nature Limited
This article is cited by
-
Radial glia fibers translate Fgf8 morphogenetic signals to generate a thalamic nuclear complex protomap in the mantle layer
Brain Structure and Function (2019)
-
A parental requirement for dual-specificity phosphatase 6 in zebrafish
BMC Developmental Biology (2018)
-
Fgf15 regulates thalamic development by controlling the expression of proneural genes
Brain Structure and Function (2016)
-
The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis
Nature Cell Biology (2006)
-
Comparative Mechanisms of Branching Morphogenesis in Diverse Systems
Journal of Mammary Gland Biology and Neoplasia (2006)