Many cellular functions are carried out by proteins that are bound together in complexes. In two new large-scale studies, labelled proteins are used as 'bait' to capture and identify those complexes.
This is a preview of subscription content, log in via an institution to check access.
References
Gavin, A.-C. et al. Nature 415, 141–147 (2002).
Ho, Y. et al. Nature 415, 180–183 (2002).
Uetz, P. et al. Nature 403, 623–627 (2000).
Ito, T. et al. Proc. Natl Acad. Sci. USA 98, 4569–4574 (2001).
Zhu, H. et al. Science 293, 2101–2105 (2001).
Gelperin, D. et al. Proc. Natl Acad. Sci. USA 92, 11539–11543 (1995).
Roberts, R. L. et al. Cell 89, 1055–1065 (1997).
Beck, T. & Hall, M. N. Nature 402, 689–692 (1999).
Guzder, S. N., Sung, P., Prakash, L. & Prakash, S. J. Biol. Chem. 273, 31541–31546 (1998).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Kumar, A., Snyder, M. Protein complexes take the bait. Nature 415, 123–124 (2002). https://doi.org/10.1038/415123a
Issue Date:
DOI: https://doi.org/10.1038/415123a
- Springer Nature Limited
This article is cited by
-
Identifying spreading influence nodes for social networks
Frontiers of Engineering Management (2022)
-
Protein interaction networks: centrality, modularity, dynamics, and applications
Frontiers of Computer Science (2021)
-
A survey of computational methods in protein–protein interaction networks
Annals of Operations Research (2019)
-
Methylated-antibody affinity purification to improve proteomic identification of plant RNA polymerase Pol V complex and the interacting proteins
Scientific Reports (2017)
-
Improved method for protein complex detection using bottleneck proteins
BMC Medical Informatics and Decision Making (2013)