Skip to main content

Advertisement

SpringerLink
Log in

When accessories turn out to be essential

  • News & Views
  • Published:

From Nature Medicine

View current issue Submit your manuscript

Abstract

New findings demonstrate that the accessory proteins of primate lentiviruses are molecular tricksters that hold the strings to the pathogenesis of AIDS (pages 1397–1408).

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Simon, J.H.M, Gaddis, N.C., Fouchier, R.A.M. & Malim, M.H. Evidence for a newly discovered cellular anti-HIV-1 phenotype. Nature Med. 4, 1397–1400 (1998).

    Article  CAS  Google Scholar 

  2. Hirsch, V.M. et al. Vpx is required for dissemination and pathogenesis of SIVSM PBJ: Evidence for macrophage-dependent viral amplification. Nature Med. 4, 1401–1408 (1998).

    Article  CAS  Google Scholar 

  3. Simon, J.H.M. & Malim, M.H. The human immunodeficiency virus type 1 Vif protein modulates the post-penetration stability of viral nucleoprotein complexes. J. Virol. 70, 5297–5305 (1996).

    CAS  PubMed  PubMed Central  Google Scholar 

  4. Gabuzda, D.H. et al. Role of vif in replication of human immunodeficiency virus type 1 in CD4+ lymphocytes. J. Virol. 66, 6489–6495 (1992).

    CAS  PubMed  PubMed Central  Google Scholar 

  5. Simon, J.H.M. et al. The regulation of primate immunodeficiency virus infectivity by Vif is cell species restricted: A role for Vif in determining virus host-range and cross-species transmission. EMBO J. 17, 1259–1267 (1998).

    Article  CAS  Google Scholar 

  6. Duran-Troise, G., Bassin, R.H., Rein, A. & Gerwin, B.I. Loss of Fv-1 restriction in Balb/3T3 cells following infection with a single N-tropic murine leukemia virus particle. Cell 10, 479–488 (1981).

    Article  Google Scholar 

  7. Fultz, P.N. & Zack, P.M. Unique lentivirus-host interaction: SIVSMMPBj14 infection of macaques. Virus Res. 32, 205–225 (1994).

    Article  CAS  Google Scholar 

  8. Du, Z. et al. Identification of a nef allele that causes lymphocyte activation and acute disease in macaque monkeys. Cell 82, 655–674 (1995).

    Article  Google Scholar 

  9. Schmidtmayerova, H. et al. Human immunodeficiency virus type 1 infection alters chemokine β peptide expression in human monocytes: Implications for recruitment of leukocytes into brains and lymph nodes. Proc. Natl. Acad. Sci. USA 93, 700–704 (1996).

    Article  CAS  Google Scholar 

  10. Hanna, Z. et al. Nef harbors a major determinant of pathogenicity for an AIDS-like disease induced by HIV-1 in transgenic mice. Cell 95, 163–175 (1998).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Genetics and Microbiology CMU, Geneva, CH-1211 4, Switzerland

    Didier Trono

Authors
  1. Didier Trono
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Trono, D. When accessories turn out to be essential. Nat Med 4, 1368–1369 (1998). https://doi.org/10.1038/3953

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/3953

  • Springer Nature America, Inc.

This article is cited by

Search

Navigation