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The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI

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Abstract

The nucleotide sequence of the 948,061 base pairs of chromosome XVI has been determined, completing the sequence of the yeast genome. Chromosome XVI was the last yeast chromosome identified1, and some of the genes mapped early to it, such as GAL4, PEP4 and RAD1(ref. 2) have played important roles in the development of yeast biology. The architecture of this final chromosome seems to be typical of the large yeast chromosomes, and shows large duplications with other yeast chromosomes. Chromosome XVI contains 487 potential protein-encoding genes, 17 tRNA genes and two small nuclear RNA genes; 27% of the genes have significant similarities to human gene products, and 48% are new and of unknown biological function. Systematic efforts to explore gene function have begun.

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Author notes

  1. D.H. Vo and J. Hani: These authors contributed equally to the work.

Authors and Affiliations

  1. Department of Biology, McGill University, 1205 Dr Penfield Avenue, Montreal, H3A 1B1, Canada

    H. Bussey, T. DiPaolo, N. Fortin, J. Hall, A. M. Sdicu, Y. Wang, E. Winnett, W-W. Zhong & D. H. Vo

  2. Department of Biology, Concordia University, Montreal, H3G 1M8, Canada

    R. K. Storms & S. Ushinsky

  3. Research Institute, Hospital for Sick Children, Toronto, M5G 1X8, Canada

    A. Ahmed & J. D. Friesen

  4. Martinsrieder Institut für Protein Sequenzen, Max-Planck-Institut für Biochemie, D-82152, Martinsried, Germany

    K. Albermann, K. Heumann, K. Kleine, H. W. Mewes, A. Zollner & J. Hani

  5. Department of Biochemistry, Stanford University, Stanford, California, 94305, USA

    E. Allen, R. Araujo, A. Aparicio, D. Botstein, J. Carpenter, J. M. Cherry, E. Chung, K. Davis, R. W. Davis, F. S. Dietrich, M. Duncan, S. Hunicke-Smith, R. Hyman, S. Kalman, C. Komp, O. Kurdi, D. Lashkari, H. Lew, A. Lin, D. Lin, R. Marathe, S. Mirtipati, A. Namath, P. Oefner, F. X. Petel, D. Roberts, S. Schramm & M. Schröder

  6. European Molecular Biology Laboratory, Meyerhofstrasse 1, D-69117, Heidelberg, Germany

    W. Ansorge, V. Benes, U. Nentwich, S. Rechmann & H. Voss

  7. The Sanger Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK

    B. Barrell, K. Badcock, S. Bowman, C. Churcher, D. Pearson, M. A. Rajandream & S. V. Walsh

  8. Genotype GmbH, D-69259, Wilhelmsfeld, Germany

    M. Brückner, S. Müller-Auer, M. Rieger & M. Schäfer

  9. Unité de Biochimie Physiologique, Université Catholique de Louvain, Louvainla-Neuve, Belgium

    F. Coster, A. Goffeau, B. Purnelle & H. Tettelin

  10. DKFZ, im Neuenheimer Feld 506, D-69120, Heidelberg, Germany

    H. Delius & U. Hebling

  11. Research Institute of CERIA-COOVI, B-1070, Brussels, Belgium

    E. Dubois, F. Messenguy & F. Vierendeels

  12. Laboratoire de Microbiologie de l’Université Libre de Bruxelles, B-1050, Brussels, Belgium

    E. Dubois

  13. QIAGEN GmbH, Max-Volmer-Strasse 4, D-40724, Hilden, Germany

    A. Düsterhöft, M. Floeth, C. Fritz, H. Hilbert & D. Moestl

  14. The Genome Sequencing Center, Department of Genetics, Washington University, School of Medicine, 630 S. Euclid Avenue, St Louis, Missouri, 63110, USA

    L. Hillier, M. Johnston & L. Riles

  15. Yeast Genetics, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, OX3 9DU, UK

    E. J. Louis

  16. Gesellschaft für Analyse Technik und Consulting mbH, Fritz-Arnold-Strasse 23, D-78467, Konstanz, Germany

    T. M. Pohl

  17. AGON, Gesellschaft für molekularbiologische Technologie mbH, Glienicker Weg 185, D-12489, Berlin, Germany

    M. Scharfe, R. Wambutt, E. Wedler & H. Wedler

  18. Department Microbiologie, Vlaams Interuniversitair Instituut voor Biothechnologie, B-1070, Brussels, Belgium

    B. Scherens & S. Vissers

  19. Laboratorium voor Erfelijkheidsleer en Microbiologie van de Vrije Universiteit, Brussels, Belgium

    B. Scherens

  20. Laboratoire de Physiologie Cellulaire et de Génétique des Levures, Université Libre de Bruxelles, B-1050, Brussels, Belgium

    L. A. Urrestarazu

Authors
  1. H. Bussey
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  2. R. K. Storms
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Correspondence to H. Bussey.

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Bussey, H., Storms, R.K., Ahmed, A. et al. The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI. Nature 387 (Suppl 6632), 103–105 (1997). https://doi.org/10.1038/387s103

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  • DOI: https://doi.org/10.1038/387s103

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