Abstract
TISSUE factor, a member of the cytokine-receptor superfamily and high-affinity receptor and cofactor for plasma factor Vll/VIIa (ref. 1), is the primary cellular initiator of blood coagulation. It is involved in thrombosis and inflammation associated with sepsis, atherosclerosis and cancer2, and can participate in other cellular processes including intracellular signalling3, metastasis4, tumour-associated angiogenesis5, and embryogenesis6. Here we report that inactivation of the tissue factor gene (TF) results in abnormal circulation from yolk sac to embryo beyond embryonic day 8.5, leading to embryo wasting and death. Vitelline vessels from null mice were deficient in smooth-muscle α-actin-expres-sing mesenchymal cells, which participate in organization of the vessel wall. This implies that tissue factor has a role in bloodvessel development.
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Edgington, T. S., Mackman, N., Brand, K. & Ruf, W. Thromb. Haemost 66, 67–79 (1991).
Rickles, F. R., Levine, M. N. & Edwards, R. L. Cancer Metast. Rev. 11, 237–248 (1992).
Rottingen, J.-A., Enden, T., Camerer, E., Iversen, J.-G. & Prydz, H. J. Biol. Chem. 270, 4650–4660 (1995).
Mueller, B. M., Reisfeld, R. A., Edgington, T. S. & Ruf, W. Proc. Natl Acad. Sci. USA 89, 11832–11836 (1992).
Zhang, Y. et al. J. Clin. Invest. 94, 1320–1327 (1994).
Luther, T. et al. Am. J. Pathol. 149, 101–113 (1996).
Dickson, M. C. et al. Development 121, 1845–1854 (1995).
Dzierzak, E. & Medvinsky, A. Trends Genet. 11, 359–366 (1995).
Chen, B., Blaschuk, O. W. & Hales, B. F. Teratology 44, 581–590 (1991).
Duncan, S. A. et al. Proc. Natl Acad. Sci. USA 91, 7598–7602 (1994).
Breier, G., Clauss, M. & Risau, W. Dev. Dyn. 204, 228–239 (1995).
Dejana, E., Corada, M. & Lampugnani, G. FASEB J. 9, 910–918 (1995).
Zeitlin, S. et al. Nature Genet. 11, 155–163 (1995).
Nehls, V. & Drenckhahn, D. Histochemistry 99, 1–12 (1993).
Altieri, D. C. FASEB J. 9, 860–865 (1995).
Connolly, A., Ishihara, H., Kahn, M. L., Farese, R. V. & Coughlin, S. R. Nature 381, 516–519 (1996).
Sato, Y., Asada, Y., Marutsuka, K., Hatakeyam, K. & Sumiyoshi, A. Thromb. Haemost. 75, 389–392 (1996).
Suh, T. T. et al. Genes Dev. 9, 2020–2033 (1995).
Carmeliet, P. et al. J. Clin. Invest. 92, 2746–2755 (1993).
Carmeliet, P. et al. Nature 380, 435–439 (1996).
Gressens, P. et al. J. Neuropathol. Exp. Neurol. 51, 206–219 (1992).
Kasper, M. et al. Histochem. Cell. Biol. 104, 397–405 (1995).
Hume, D. A., Monkley, S. J. & Wainwright, B. J. Br. J. Haematol. 90, 939–405 (1995).
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Carmeliet, P., Mackman, N., Moons, L. et al. Role of tissue factor in embryonic blood vessel development. Nature 383, 73–75 (1996). https://doi.org/10.1038/383073a0
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DOI: https://doi.org/10.1038/383073a0
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