The segregation of chromosomes at mitosis and meiosis during cell division depends on their interaction with a bipolar spindle. But, surprisingly, it turns out that the spindle can form and function even in the absence of chromosomes.
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Hyams, J. Look Ma, no chromosomes!. Nature 382, 397–398 (1996). https://doi.org/10.1038/382397a0
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DOI: https://doi.org/10.1038/382397a0
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