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A receptor subtype involved in neuropeptide-Y-induced food intake

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Abstract

NEUROPEPTIDE Y (NPY) is a powerful stimulant of food intake and is proposed to activate a hypothalamic 'feeding' receptor distinct from previously cloned Y-type receptors1. This receptor was first suggested to explain a feeding response to NPY and related peptides, including NPY 2–36, that differed from their activities at the Yl receptor2. Here we report the expression cloning of a novel Y-type receptor from rat hypothalamus, which we name Y5. The complementary DNA encodes a 456-amino-acid protein with less than 35% overall identity to known Y-type receptors. The messenger RNA is found primarily in the central nervous system, including the paraventricular nucleus of the hypothalamus. The extent to which selected peptides can inhibit adenylate cyclase through the Y5 receptor and stimulate food intake in rats correspond well. Our data support the idea that the Y5 receptor is the postulated 'feeding' receptor, and may provide a new method for the study and treatment of obesity and eating disorders.

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Authors and Affiliations

  1. Synaptic Pharmaceutical Corporation, 215 College Road, Paramus, New Jersey, 07652-1431, USA

    Christophe Gerald, Mary W. Walker, Eric L. Gustafson, Kelli E. Smith, Pierre Vaysse, Margaret M. Durkin, Thomas M. Laz, David L. Linemeyer, Robert I. Taber, Theresa A. Branchek & Richard L. Weinshank

  2. Ciba-Geigy Limited, Pharmaceutical Division, Metabolic Risk Factor Department, CH-4002, Basle, Switzerland

    Leoluca Criscione, Christine Batzl-Hartmann, Andrea O. Schaffhauser, Steven Whitebread & Karl G. Hofbauer

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  1. Christophe Gerald
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  2. Mary W. Walker
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  3. Leoluca Criscione
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  5. Christine Batzl-Hartmann
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  6. Kelli E. Smith
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  7. Pierre Vaysse
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  8. Margaret M. Durkin
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  13. Karl G. Hofbauer
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  14. Robert I. Taber
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  15. Theresa A. Branchek
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  16. Richard L. Weinshank
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Gerald, C., Walker, M., Criscione, L. et al. A receptor subtype involved in neuropeptide-Y-induced food intake. Nature 382, 168–171 (1996). https://doi.org/10.1038/382168a0

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  • DOI: https://doi.org/10.1038/382168a0

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