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Structural similarity between TAFs and the heterotetrameric core of the histone octamer

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Abstract

A complex of two TFIID TATA box-binding protein-associated factors (TAFIIs) is described at 2.0 Å resolution. The amino-terminal portions of dTAFII42 and dTAFII62 from Drosophila adopt the canonical histone fold, consisting of two short α-helices flanking a long central α-helix. Like histones H3 and H4, dTAFII42 and dTAFII62 form an intimate heterodimer by extensive hydrophobic contacts between the paired molecules. In solution and in the crystalline state, the dTAFII42/dTAFII62 complex exists as a heterotetramer, resembling the (H3/H4)2 heterotetrameric core of the histone octamer, suggesting that TFIID contains a histone octamer-like substructure.

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Author notes

  1. Tetsuro Kokubo

    Present address: Division of Gene Function in Animals, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, Nara, 630-01, Japan

  2. Alexander Hoffmann

    Present address: Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, USA

Authors and Affiliations

  1. Laboratory of Molecular Biophysics, The Rockefeller University, 1230 York Avenue, New York, New York, 10021, USA

    Xiaoling Xie & Stephen K. Burley

  2. Laboratory of Mass Spectrometry and Gaseous Ion Chemistry, The Rockefeller University, 1230 York Avenue, New York, New York, 10021, USA

    Steven L. Cohen, Urooj A. Mirza & Brian T. Chait

  3. Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, 1230 York Avenue, New York, New York, 10021, USA

    Alexander Hoffmann & Robert G. Roeder

  4. Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, New York, 10021, USA

    Xiaoling Xie & Stephen K. Burley

  5. National Institutes of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, 20892, USA

    Tetsuro Kokubo & Yoshihiro Nakatani

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  1. Xiaoling Xie
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  2. Tetsuro Kokubo
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  4. Urooj A. Mirza
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  5. Alexander Hoffmann
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  6. Brian T. Chait
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  8. Yoshihiro Nakatani
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Xie, X., Kokubo, T., Cohen, S. et al. Structural similarity between TAFs and the heterotetrameric core of the histone octamer. Nature 380, 316–322 (1996). https://doi.org/10.1038/380316a0

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