Skip to main content
SpringerLink
Log in

S-nitrosohaemoglobin: a dynamic activity of blood involved in vascular control

  • Article
  • Published:

From Nature

View current issue Submit your manuscript

Abstract

A dynamic cycle exists in which haemoglobin is S-nitrosylated in the lung when red blood cells are oxygenated, and the NO group is released during arterial–venous transit. The vasoactivity of S-nitrosohaemoglobin is promoted by the erythrocytic export of S-nitrosothiols. These findings highlight newly discovered allosteric and electronic properties of haemoglobin that appear to be involved in the control of blood pressure and which may facilitate efficient delivery of oxygen to tissues. The role of S-nitrosohaemoglobin in the transduction of NO-related activities may have therapeutic applications.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Lancaster, J. R. Proc. natn. Acad. Sci. U.S.A. 91, 8137–8141 (1994).

    Article  ADS  CAS  Google Scholar 

  2. Wood, J. & Garthwaite, J. Neuropharmacology 33, 1235–1244 (1994).

    Article  CAS  Google Scholar 

  3. Gaston, B. et al. Proc. natn. Acad. Sci. U.S.A. 90, 10957–10961 (1993).

    Article  ADS  CAS  Google Scholar 

  4. Stamler, J. S. et al. Proc. natn. Acad. Sci. U.S.A. 89, 444–448 (1992).

    Article  ADS  CAS  Google Scholar 

  5. DeGroote, M. A. et al. Proc. natn. Acad. Sci. U.S.A. 92, 6399–6403 (1995).

    Article  ADS  CAS  Google Scholar 

  6. Stamler, J. C. Cell 78, 931–936 (1994).

    Article  CAS  Google Scholar 

  7. Olson, J. S. Meth. Enzym. 76, 631–651 (1981).

    Article  CAS  Google Scholar 

  8. Antonini, E. & Brunori, M. in Hemoglobin and Myoglobin in their Reactions with Ligands 29–31 (Elsevier, New York, 1971).

    Google Scholar 

  9. Scharfstein, J. S. et al. J. clin. Invest. 94, 1432–1439 (1995).

    Article  Google Scholar 

  10. Clancy, R. M. et al. Proc. natn. Acad. Sci. U.S.A. 91, 3680–3684 (1994).

    Article  ADS  CAS  Google Scholar 

  11. Toothill, C. Brit. J. Anaesth. 39, 405–412 (1967).

    Article  CAS  Google Scholar 

  12. Garel, C. et al. J. Biochem. 123, 513–519 (1982).

    CAS  Google Scholar 

  13. Jocelyn, P. C. Biochemistry of the SH Group 243 (Academic, London, 1972).

    Google Scholar 

  14. Craescu, C. T. et al. J. biol. Chem. 261, 14710–14716 (1986).

    CAS  PubMed  Google Scholar 

  15. Wennmalm, A., Benthin, G. & Petersson, A. S. Br. J. Pharmac. 106(3), 507–508 (1992).

    Article  CAS  Google Scholar 

  16. Arnelle, D. R. & Stamler, J. S. Arch. Biochem. Biophys. 318, 279–285 (1995).

    Article  CAS  Google Scholar 

  17. Vogel, W. M. et al. Am. J. Physiol. 251, H413–H420 (1986).

    ADS  CAS  PubMed  Google Scholar 

  18. Olsen, S. B. et al. Circulation 93, 329–332 (1996).

    Article  Google Scholar 

  19. Stamler, J. S. et al. Proc. natn. Acad. Sci. U.S.A. 89, 7674–7677 (1992).

    Article  ADS  CAS  Google Scholar 

  20. Kondo, T., Dale, G. L. & Beutler, E. Meth. Enzym. 252, 72–83 (1995).

    Article  CAS  Google Scholar 

  21. Bolotina, V. M. et al. Nature 368, 850–853 (1994).

    Article  ADS  CAS  Google Scholar 

  22. Salhany, J. M. & Gaines, K. C. Trends biochem. Sci. Jan, 1–3 (1981).

  23. Mansouri, A. Biochem. biophys. Res. Commun. 89, 441–447 (1979).

    Article  CAS  Google Scholar 

  24. Kilbourn, R. G. et al. Biochem. biophys. Res. Commun. 199, 155–162 (1994).

    Article  CAS  Google Scholar 

  25. Beckman, J. S., Wink, D. & Crow, J. P. in Methods in Nitric Oxide Research (eds Feelisch, M. & Stamler, J. S.) (Wiley, Chichester, UK, 1996).

    Google Scholar 

  26. Shen, W., Hintze, T. H. & Wolin, M. S. Circulation 92, 3505–3512 (1995).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Medicine, Divisions of Respiratory and Cardiovascular Medicine, Duke University Medical Center, MSRB Building, Room 321, Box 2612, Durham, North Carolina, 27710, USA

    Li Jia & Jonathan S. Stamler

  2. Department of Cell Biology, Duke University Medical Center, MSRB Building, Room 321, Box 2612, Durham, North Carolina, 27710, USA

    Celia Bonaventura, Joseph Bonaventura & Jonathan S. Stamler

  3. Nicholas School of the Environment, Duke Marine Biomedical Center, Rivers Island, North Carolina, 28516, USA

    Celia Bonaventura & Joseph Bonaventura

Authors
  1. Li Jia
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Celia Bonaventura
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Joseph Bonaventura
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Jonathan S. Stamler
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Jia, L., Bonaventura, C., Bonaventura, J. et al. S-nitrosohaemoglobin: a dynamic activity of blood involved in vascular control. Nature 380, 221–226 (1996). https://doi.org/10.1038/380221a0

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/380221a0

  • Springer Nature Limited

This article is cited by

Search

Navigation