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MSH2 genomic deletions are a frequent cause of HNPCC

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Figure 1: Mapping of MSH2 deletions responsible for HNPCC.
Figure 2: Nucleotide sequence analysis of deleted MSH2 transcripts.

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Acknowledgements

The authors are grateful to M. de Almeida for technical assistance and the following clinicians for contributing their HNPCC families: F. Nagengast, A. Bröcker-Vriends, G. Griffioen, A. Cats and J. Kleibeuker. This work has been supported in part by the Dutch Cancer Society and Praeventiefonds (project no. PRF 28-1383-1).

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Authors and Affiliations

  1. MGC-Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands

    Juul Wijnen, Heleen van der Klift, P. Meera Khan & Ricardo Fodde.

  2. The Foundation for the Detection of Hereditary Tumors, and Department of Gastroenterology, Leiden University Medical Center, Leiden, The Netherlands

    Hans Vasen

  3. Department of Clinical Genetics, Free University Hospital, Amsterdam, The Netherlands

    Fred Menko

  4. Clinical Genetic Center Leiden, Leiden University Medical Center, Leiden, The Netherlands

    Carli Tops

  5. MGC-Department of Clinical Genetics, Erasmus University Rotterdam, Rotterdam, The Netherlands

    Hanne Meijers Heijboer & Dick Lindhout

  6. The Norwegian Radium Hospital, Oslo, Norway

    Pål Møller

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  1. Juul Wijnen
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  2. Heleen van der Klift
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  7. Hanne Meijers Heijboer
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  10. Ricardo Fodde.
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Correspondence to Ricardo Fodde..

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Wijnen, J., van der Klift, H., Vasen, H. et al. MSH2 genomic deletions are a frequent cause of HNPCC. Nat Genet 20, 326–328 (1998). https://doi.org/10.1038/3795

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