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Suppression of psychoactive effects of cocaine by active immunization

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Abstract

COCAINE is a powerfully addictive substance and new strategies are needed to treat its abuse. Generating an active immunization1,2 to cocaine offers a means of blocking the actions of the drug by preventing it from entering the central nervous system, and should have fewer side effects than treatments based on manipulation of central neurotransmitter function. The design and preparation of a cocaine immunogen requires special regard for the stability of cocaine both free and as a haptenic determinant. Immunochemistry and a well defined behavioural model were brought together to address the problem of inactivation of the psychostimulant actions of cocaine. We report here that active immunization with a new, stable cocaine conjugate suppressed locomotor activity and stereotyped behaviour in rats induced by cocaine but not by amphetamine. Moreover, following acute injection of cocaine, levels of cocaine in the striatum and cerebellum of the immunized animals were lower than those of control animals. These results suggest that immunopharmacotherapy may be a promising means by which to explore new treatments for cocaine abuse.

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References

  1. Spector, S., Berkowitz, B., Flynn, E. J. & Peskar, B. Pharmac. Rev. 25, 281–291 (1973).

    CAS  Google Scholar 

  2. Berkowitz, B. & Spector, S. Science 178, 1290–1292 (1972).

    Article  ADS  CAS  Google Scholar 

  3. Garrett, E. R. & Seyda, K. J. pharm. Sci. 72, 258–271 (1983).

    Article  CAS  Google Scholar 

  4. Stewart, D. J., Inaba, T. & Kalow, W. Clin. Pharmac. Ther. 25, 464–468 (1979).

    Article  CAS  Google Scholar 

  5. Cunningham, K. A. & Lakoski, J. M. Neuropsychopharmacology 3, 41–50 (1990).

    CAS  PubMed  Google Scholar 

  6. Matsubara, K., Kagawa, M. & Fukui, Y. Forensic Sci. Int. 26, 169–180 (1984).

    Article  CAS  Google Scholar 

  7. Taussig, M. J. Curr. Top. Microbiol. Immun. 60, 125–174 (1973).

    Article  CAS  Google Scholar 

  8. Misra, A. L. et al. Res. Commun. Chem. Path. Pharmac. 13, 579–584 (1976).

    CAS  Google Scholar 

  9. Bagasra, O., Forman, L. J., Howeedy, A. & Whittle, P. Immunopharmacology 23, 173–179 (1992).

    Article  CAS  Google Scholar 

  10. Gallacher, G. Immunopharmacology 27, 79–81 (1994).

    Article  CAS  Google Scholar 

  11. Kelly, P. H. & Iversen, S. D. Eur. J. Pharmac. 40, 45–56 (1976).

    Article  CAS  Google Scholar 

  12. Lyon, M. & Robbins, T. W. in Current Developments in Psychopharmacology Vol. 2, 89–163 (eds Essman, W. & Valzelli, L.) (Spectrum, New York, 1975).

    Google Scholar 

  13. Minden, P. & Farr, R. S. in Handbook of Experimental Immunology (ed. Weir, D. M.) 463–492 (Davis Co., Philadelphia, 1967).

    Google Scholar 

  14. Steward, M. W. & Steensgaard, J. Antibody Affinity: Thermodynamic Aspects and Biological Significance (CRC Press, Boca Raton, FL, 1983).

    Google Scholar 

  15. Eisen, H. N. (ed.) in Methods in Medical Research 106–114 (Year Book Medical Publishers, Chicago, 1964).

  16. Hill, J. H., Wainer, B. H., Fitch, F. W. & Rothberg, R. M. Clin. exp. Immun. 15, 213–224 (1973).

    CAS  PubMed  Google Scholar 

  17. Benuck, M., Lajtha, A. & Reith, M. E. A. J. Pharmac. exp. Ther. 243, 144–149 (1987).

    CAS  Google Scholar 

  18. Ritz, M. C., Lamb, R. J., Goldberg, S. R. & Kuhar, M. J. Science 237, 1219–1223 (1987).

    Article  ADS  CAS  Google Scholar 

  19. Fischman, M., Schuster, C. R. & Hitano, Y. Pharmac. Biochem. Behav. 18, 123–127 (1983).

    Article  CAS  Google Scholar 

  20. Javaid, J., Fischman, M. W., Schuster, C. R., Dekirmenjian, H. & Davis, J. M. Science 202, 227–228 (1978).

    Article  ADS  CAS  Google Scholar 

  21. Landry, D. W., Zhao, K., Yang, G. X.-Q., Glickman, M. & Georgiadis, T. M. Science 259, 1899–1901 (1993).

    Article  ADS  CAS  Google Scholar 

  22. Gold, L. H. & Koob, G. F. Pharmac. Biochem. Behav. 29, 645–648 (1988).

    Article  CAS  Google Scholar 

  23. Fray, P. J. et al. Psychopharmacology 69, 253–259 (1980).

    Article  CAS  Google Scholar 

  24. Robbins, T. W. in Handbook of Psychopharmacology (eds Iversen, L., Iversen, S. & Snyder, S.) 37–82 (Plenum, New York, 1977).

    Book  Google Scholar 

  25. Kullback, S. Information Theory and Statistics (Dover, New York, 1968).

    MATH  Google Scholar 

  26. Kelly, P. H., Seviour, P. W. & Iversen, S. D. Brain Res. 94, 507–522 (1975).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Neuropharmacology, The Scripps Research Institute, 10666 North Torrey Pines Road, La Jolla, California, 92037, USA

    M. Rocío A. Carrera & Loren H. Parsons

  2. Departments of Molecular Biology and Chemistry, The Scripps Research Institute, 10666 North Torrey Pines Road, La Jolla, California, 92037, USA

    Jon A. Ashley, Peter Wirsching & Kim D. Janda

Authors
  1. M. Rocío A. Carrera
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  2. Jon A. Ashley
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  3. Loren H. Parsons
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  4. Peter Wirsching
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  5. George F. Koob
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  6. Kim D. Janda
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Carrera, M., Ashley, J., Parsons, L. et al. Suppression of psychoactive effects of cocaine by active immunization. Nature 378, 727–730 (1995). https://doi.org/10.1038/378727a0

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  • DOI: https://doi.org/10.1038/378727a0

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