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Behavioural and cardiovascular effects of disrupting the angiotensin II type-2 receptor gene in mice

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A Correction to this article was published on 28 March 1996

Abstract

ANGIOTENSIN II, a potent regulator of blood pressure and of water and electrolyte balance, binds to two different G-protein-coupled receptors. The type-1 receptor (AT1,) mediates the vasopressive and aldosterone-secreting effects of angiotensin II, but the function of the type-2 receptor (AT2; refs 1, 2) is unknown, although it is expressed in both adult3 and embryonic4 life. To address this question, we have generated mice lacking the gene encoding the AT2 receptor. Mutant mice develop normally, but have an impaired drinking response to water deprivation as well as a reduction in spontaneous movements. Their baseline blood pressure is normal, but they show an increased vasopressor response to injection of angiotensin II. Thus, although the AT2 receptor is not required for embryonic development, it plays a role in the central nervous system and cardiovascular functions that are mediated by the renin-angiotensin system.

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Author notes

  1. Brian K. Kobilka: To Whom correspondence should be addressed.

Authors and Affiliations

  1. Falk Cardiovascular Research Center and Department of Medicine, Stanford University, Stanford, California, 94305, USA

    Lutz Hein, Richard E. Pratt, Victor J. Dzau & Brian K. Kobilka

  2. Departments of Genetics and Pediatrics, Stanford University, Stanford, California, 94305, USA

    Gregory S. Barsh

  3. Howard Hughes Medical Institute, Stanford University, Stanford, California, 94305, USA

    Gregory S. Barsh & Brian K. Kobilka

Authors
  1. Lutz Hein
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  2. Gregory S. Barsh
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  3. Richard E. Pratt
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  4. Victor J. Dzau
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  5. Brian K. Kobilka
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Hein, L., Barsh, G., Pratt, R. et al. Behavioural and cardiovascular effects of disrupting the angiotensin II type-2 receptor gene in mice. Nature 377, 744–747 (1995). https://doi.org/10.1038/377744a0

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