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Structure of serum response factor core bound to DNA

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Abstract

The human serum response factor is a transcription factor belonging to the MADS domain protein family with members characterized from the plant and animal kingdoms. The X-ray crystal structure of the serum response factor core in a specific-recognition DNA complex shows that the functions of DNA binding, dimerization and accessory-factor interaction are compactly integrated into a novel protein unit. The intrinsic and induced conformation of the serum response element DNA is the principal DNA feature recognized in the specific complex.

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Author notes

  1. Timothy J. Richmond: To whom correspondence should be addressed.

Authors and Affiliations

  1. Institut für Molekularbiologie und Biophysik, ETH-Hönggerberg, CH-8093, Zürich, Switzerland

    Luca Pellegrini, Song Tan & Timothy J. Richmond

Authors
  1. Luca Pellegrini
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  2. Song Tan
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  3. Timothy J. Richmond
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Pellegrini, L., Tan, S. & Richmond, T. Structure of serum response factor core bound to DNA. Nature 376, 490–498 (1995). https://doi.org/10.1038/376490a0

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