Skip to main content
SpringerLink
Log in

Hippocampal long-term potentiation and neural cell adhesion molecules L1 and NCAM

  • Letter
  • Published:

From Nature

View current issue Submit your manuscript

Abstract

SYNAPTIC membranes express cell adhesion molecules1. Here we investigate the role of the neural cell adhesion molecules L1 and NCAM in hippocampal long-term potentiation (LTP), a sustained-use-dependent increase in synaptic efficacy that has been impli-cated in learning and memory2. L1 and NCAM mediate cell inter-actions during neural development3 and are strongly expressed in the hippocampus4,5. They cooperate to strengthen L1-dependent cell adhesion6–9 and are coupled to second messenger pathways10–12. We show that LTP in CA1 neurons of rat hippo-campal slices was reduced by application of various L1 and NCAM antibodies, recombinant LI fragments, and upon dissociation of the L1/NCAM complex through oligomannosidic carbohydrates and NCAM peptides. Neither the activation of NMDA (N-methyl-D-aspartate) receptors nor the maintenance of LTP was affected. These results suggest that L1 and NCAM modulate the develop-ment or the stabilization of LTP13.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Persohn, E., Pollerberg, G. E. & Schachner, M. J. comp. Neurol. 288, 92–100 (1989).

    Article  CAS  Google Scholar 

  2. Bliss, T. V. P. & Collingridge, G. L. Nature 361, 31–39 (1993).

    Article  ADS  CAS  Google Scholar 

  3. Edelman, G. M. A. Rev. Cell Biol. 2, 81–116 (1986).

    Article  CAS  Google Scholar 

  4. Miller, P. D., Chung, W.-W., Lagenaur, C. F. & DeKosky, S. T. J. comp. Neurol. 327, 341–349 (1993).

    Article  CAS  Google Scholar 

  5. Persohn, E. & Schachner, M. J. Cell Biol. 105, 569–576 (1987).

    Article  CAS  Google Scholar 

  6. Simon, H., Klinz, S., Fahrig, T. & Schachner, M. Eur. J. Neurosci. 3, 634–640 (1991).

    Article  Google Scholar 

  7. Kadmon, G. A., Kowitz, P., Altevogt, P. & Schachner, M. J. Cell Biol. 110, 193–208 (1990).

    Article  CAS  Google Scholar 

  8. Horstkorte, R., Schachner, M., Magyar, J. P., Vorherr, T. & Schmitz, B. J. Cell Biol. 121, 1409–1421 (1993).

    Article  CAS  Google Scholar 

  9. Zhang, H., Miller, R. H. & Rutishauser, U. J. Neurosci. 12, 3107–3114 (1992).

    Article  CAS  Google Scholar 

  10. Doherty, P. & Walsh, F. S. Curr. Opin. Neurobiol. 4, 49–55 (1994).

    Article  CAS  Google Scholar 

  11. von Bohlen und Halbach, F., Taylor, J. & Schachner, M. Eur. J. Neurosci. 4, 896–909 (1992).

    Article  Google Scholar 

  12. Atashi, J. et al. Neuron 8, 831–842 (1992).

    Article  CAS  Google Scholar 

  13. Hanse, E. & Gustafsson, B. Neurosci. Res. 20, 15–25 (1994).

    Article  CAS  Google Scholar 

  14. Larson, J. & Lynch, G. Science 232, 985–988 (1986).

    Article  ADS  CAS  Google Scholar 

  15. Lindner, J., Rathjen, F. G. & Schachner, M. Nature 305, 427–430 (1983).

    Article  ADS  CAS  Google Scholar 

  16. Appel, F., Holm, J., Consience, J.-F. & Schachner, M. J. Neurosci. 13, 4764–4775 (1993).

    Article  CAS  Google Scholar 

  17. Lemmon, F., Farr, K. L. & Lagenaur, C. Neuron 2, 1597–1603 (1989).

    Article  CAS  Google Scholar 

  18. Bailey, C. H. & Kandel, E. R. A. Rev. Physiol. 55, 397–426 (1993).

    Article  CAS  Google Scholar 

  19. Greenough, W. T. & Bailey, C. H. Trends Neurosci. 11, 142–147 (1988).

    Article  Google Scholar 

  20. Scholey, A. B., Rose, S. P. R., Zamani, M. R., Bock, E. & Schachner, M. Neuroscience 55, 499–509 (1993).

    Article  CAS  Google Scholar 

  21. Doyle, E., Nolan, P., Bell, R. & Regan, C. M. J. Neurochem. 59, 1570–1573 (1992).

    Article  CAS  Google Scholar 

  22. Doyle, E., Nolan, P., Bell, R. & Regan, C. M. J. Neurosci. Res. 31, 513–523 (1992).

    Article  CAS  Google Scholar 

  23. Cremer, H. et al. Nature 367, 455–459 (1994).

    Article  ADS  CAS  Google Scholar 

  24. Rathjen, F. G. & Schachner, M. EMBO J. 3, 1–10 (1984).

    Article  CAS  Google Scholar 

  25. Blanton, M., Lo Turco, J. & Kriegstein, A. J. neurosci. Meth. 30, 203–210 (1989).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Pharma Division, Preclinical Research, F. Hoffmann-La Roche Ltd, CH-4002, Basel, Switzerland

    Andreas Lüthi & Jean-Paul Laurent

  2. Department of Pharmacology, Centre Medical Universitaire, CH-1211, Geneve, 4, Switzerland

    Alexander Figurovt & Dominique Mullert

  3. Department of Neurobiology, Swiss Federal Institute of Technology, HÖnggerberg, CH-8093, Zurich, Switzerland

    Melitta Schachnert

Authors
  1. Andreas Lüthi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jean-Paul Laurent
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Alexander Figurovt
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Dominique Mullert
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Melitta Schachnert
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lüthi, A., Laurent, JP., Figurovt, A. et al. Hippocampal long-term potentiation and neural cell adhesion molecules L1 and NCAM. Nature 372, 777–779 (1994). https://doi.org/10.1038/372777a0

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/372777a0

  • Springer Nature Limited

This article is cited by

Search

Navigation