Abstract
THROUGH cognate B-cell–T-cell interactions and provision of cytokines, CD4+ T-cell antigen receptor (TCR) αβ+ T cells regulate immunoglobulin isotype synthesis1. Murine IgGl and IgE secretion is therefore substantially T-cell-dependent, whereas IgM and IgG3 secretion is not2, 3. Here we report that in the absence of αβ T cells, B cells expand, differentiate and secrete copious amounts of antibodies of ‘T-dependent’ isotypes. Moreover, the antibodies are reactive towards self-antigens, as in patients with systemic lupus erythematosus, so autoantibodies of ‘ T-dependent type can develop without the help of CD4+ αβ T cells. This phenotype is not evident in mice or humans that are congenitally deficient in specific αβ T-cell functions, but bears comparison with B-cell hyperactivity and autoimmunity in transplant rejection and in immunodeficiencies such as AIDS4, 5.
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References
Isakson, P. C., Pure, E., Vitetta, E. S. & Krammer, P. J. J. exp. Med., 155, 734–748 (1982).
Wortis, H. H. & Taylor, R. B. Nature 220, 927–928 (1968).
Martinez-A, C., Coutinho, A. & Augustin, A. Eur. J. Immun. 10, 698–702 (1980).
Goldman, M., Druet, P. & Gleichmann, E. Immun. Today 12, 223–227 (1991).
Morrow, W. J., Isenberg, D. A., Sobol, R. E., Stricker, R. B. & Kieber-Emmons, T. Clin. Immun. Immunopath. 58, 163–180 (1991).
Philpott, K. et al. Science 256, 1448–1452 (1992).
Mombaerts, P., Arnoldi, J., Russ, F., Tonegawa, S. & Kaufmann, S. H. E. Nature 365, 53–56 (1993).
Tsuji, M. et al. Proc. natn. Acad. Sci. U.S.A. 91, 345–349 (1994).
Pritchard, H., Riddaway, J. & Micklem, H. S. Clin. exp. Immun. 13, 125–138 (1973).
Goodnow, C. C. A. Rev Immun. 10, 489–518 (1992).
Andrews, B. S. et al. J. exp. Med. 148, 1198–1215 (1978).
Dresser, D. W. Nature 274, 480–482 (1978).
Van Snick, J. L. & Masson, P. L. J. exp. Med. 151, 45–55 (1980).
Klinman, D. M. J. Immun. 148, 1353–1358 (1992).
Souroujon, M., White-Scharf, M., Andre-Scwartz, J., Gefter, M. & Schwartz, R. S. J. Immun. 140, 4173–4179 (1988).
Klinman, D. M., Eisenberg, R. A. & Steinberg, A. D. J. Immun. 144, 506–511 (1990).
Fish, F. & Ziff, M. J. Immun. 128, 409–414 (1982).
Fatenejad, S., Mamula, M. & Craft, J. E. Proc. natn. Acad. Sci. U.S.A. 90, 12010–12014 (1993).
Cosgrove, D. et al. Cell 66, 1051–1066 (1991).
Kikutani, H. et al. Cell 47, 657–668 (1986).
Rajagopolan, S., Zordan, T., Tsokos, G. C. & Datta, S. K. Proc. natn. Acad. Sci. U.S.A. 87, 7020–7024 (1990).
Sano, Y. et al. Immunology 80, 388–394 (1993).
Korthauer, U. Nature 361, 539–541 (1993).
Purkeson, J. & Isakson, P. C. J. exp. Med. 175, 973–982 (1992).
Shlomchik, M. et al. J. exp. Med. 171, 265–297 (1990).
Jevnikar, A. M., Grusby, M. J. & Glimcher, L. J. exp. Med. 178, 1137–1144 (1994).
Koh, D-R. et al. Science 256, 1210–1213 (1992).
Like, A., Appel, M. C. & Rossini, A. A. Diabetes 31, 816–820 (1988).
De Paoli, P. et al. Clin. exp. Immun. 83, 187–191 (1991).
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Wen, L., Roberts, S., Viney, J. et al. Immunoglobulin synthesis and generalized autoimmunity in mice congenitally deficient in αβ(+) T cells. Nature 369, 654–658 (1994). https://doi.org/10.1038/369654a0
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DOI: https://doi.org/10.1038/369654a0
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