Abstract
A linkage map of the human genome has been constructed based on the segregation analysis of 814 newly characterized polymorphic loci containing short tracts of (C-A)n repeats in a panel of DNAs from eight large families. Statistical linkage analysis placed 813 of the markers into 23 linkage groups corresponding to the 22 autosomes and the X chromosome; 605 show a heterozygosity above 0.7 and 553 could be ordered with odds ratios above 1,000:1. The distance spanned corresponds to ∼90% of the estimated length of the human genome.
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Weissenbach, J., Gyapay, G., Dib, C. et al. A second-generation linkage map of the human genome. Nature 359, 794–801 (1992). https://doi.org/10.1038/359794a0
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DOI: https://doi.org/10.1038/359794a0
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