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CD43, a molecule defective in Wiskott-Aldrich syndrome, binds ICAM-1

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Abstract

THE protein CD43 (also known as sialophorin, leukosialin, large sialoglycoprotein or gp115) is expressed on the surface of T lymphocytes, monocytes, neutrophils, platelets and some B lymphocytes1–6. Expression of CD43 is deficient and/or defective in the X-chromosome-linked immunodeficiency disorder Wiscott-Aldrich syndrome7, suggesting that CD43 might have a role in T-cell activation. We have shown that expression of human CD43 in an HLA-DR-specific murine T-cell hybridoma enhances the antigen-specific response to stimulation by the human lympho-blastoid cell line Daudi, and that Daudi cells bind specifically to purified immobilized CD43 (ref. 8). These data indicate that the specific interaction of CD43 with a ligand on the surface of Daudi cells might contribute to T-cell activation. Here we report evidence that intercellular adhesion molecule-1 (ICAM-1, or CD54), is a ligand for CD43.

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Authors and Affiliations

  1. Division of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, 02115, USA

    Yvonne Rosenstein, John K. Park, William C. Hahn, Barbara E. Bierer & Steven J. Burakoff

  2. The Center for Blood Research, Harvard Medical School, Boston, Massachusetts, 02115, USA

    Fred S. Rosen

  3. Hematology-Oncology Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, 02115, USA

    Barbara E. Bierer

  4. The Department of Pathology, Harvard Medical School, Boston, Massachusetts, 02115, USA

    Yvonne Rosenstein

  5. The Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, 02115, USA

    Fred S. Rosen & Steven J. Burakoff

  6. The Department of Medicine, Harvard Medical School, Boston, Massachusetts, 02115, USA

    Barbara E. Bierer

Authors
  1. Yvonne Rosenstein
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  2. John K. Park
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  3. William C. Hahn
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  4. Fred S. Rosen
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  5. Barbara E. Bierer
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  6. Steven J. Burakoff
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Rosenstein, Y., Park, J., Hahn, W. et al. CD43, a molecule defective in Wiskott-Aldrich syndrome, binds ICAM-1. Nature 354, 233–235 (1991). https://doi.org/10.1038/354233a0

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  • DOI: https://doi.org/10.1038/354233a0

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