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Gene expression

The odd coupling

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Gene expression requires several complex biochemical reactions to be carried out precisely. These reactions must also be coordinated, and molecular biologists now have a better handle on how that happens.

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Figure 1: A model to explain coupling between the splicing of precursor messenger RNAs (pre-mRNAs) and the export of the mature mRNA product from the nucleus.

References

  1. Luo, M.-J et al. Nature 413, 644–647 (2001).

    Article  ADS  CAS  Google Scholar 

  2. Sträßer, K. & Hurt, E. Nature 413, 648–652 (2001).

    Article  ADS  Google Scholar 

  3. Luo, M. & Reed, R. Proc. Natl Acad. Sci. USA 96, 14937–14942 (1999).

    Article  ADS  CAS  Google Scholar 

  4. Zhou, Z. et al. Nature 407, 401–405 (2000).

    Article  ADS  CAS  Google Scholar 

  5. Bruhn, L., Munnerlyn, A. & Grosschedl, R. Genes Dev. 11, 640–653 (1997).

    Article  CAS  Google Scholar 

  6. Stutz, F. et al. RNA 6, 638–650 (2000).

    Article  CAS  Google Scholar 

  7. Virbasius, C. M., Wagner, S. & Green, M. R. Mol. Cell 4, 219–228 (1999).

    Article  CAS  Google Scholar 

  8. Sträßer, K. & Hurt, E. C. EMBO J. 19, 410–420 (2000).

    Article  Google Scholar 

  9. Lykke-Andersen, J. Curr. Biol. 11, R88–R91 (2001).

    Article  CAS  Google Scholar 

  10. Fleckner, J., Zhang, M., Valcarcel, J. & Green, M. R. Genes Dev. 11, 1864–1872 (1997).

    Article  CAS  Google Scholar 

  11. Staley, J. P. & Guthrie, C. Cell 92, 315–326 (1998).

    Article  CAS  Google Scholar 

  12. Kistler, A. L. & Guthrie, C. Genes Dev. 15, 42–49 (2001).

    Article  CAS  Google Scholar 

  13. Libri, D., Graziani, N., Saguez, C. & Boulay, J. Genes Dev. 15, 36–41 (2001).

    Article  CAS  Google Scholar 

  14. Zhang, M. & Green, M. R. Genes Dev. 15, 30–35 (2001).

    Article  Google Scholar 

  15. Huang, Y. & Steitz, J. A. Mol. Cell 7, 899–905 (2001).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Howard Hughes Medical Institute and the Programs in Gene Function and Expression, and Molecular Medicine, University of Massachusetts Medical School, Worcester, 01605, Massachusetts, USA

    R. Andrew Keys & Michael R. Green

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  1. R. Andrew Keys
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  2. Michael R. Green
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Correspondence to Michael R. Green.

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Keys, R., Green, M. The odd coupling. Nature 413, 583–585 (2001). https://doi.org/10.1038/35098172

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