Many organisms use natural peptides to ward off microbes, but it's proved hard to make similar molecules for medical use. A ring-shaped peptide that might puncture microbial membranes could be the way forward.
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References
Neu, H. C. Science 257, 1064–1073 (1992).
Fernandez-Lopez, S. et al. Nature 412, 452–455 (2001).
Lehrer, R. I., Ganz, T. & Selsted, M. E. Cell 64, 229–230 (1991).
Boman, H. G. Cell 65, 205–207 (1991).
Garcia-Olmedo, F., Molina, A., Alamillo, J. M. & Rodriguez-Palenzuela, P. Biopolymers 47, 479–491 (1998).
Huang, H. W. Biochemistry 39, 8347–8352 (2000).
Shai, Y. Biochim. Biophys. Acta 1462, 55–70 (1999).
Matsuzaki, K. Biochim. Biophys. Acta 1376, 391–400 (1998).
Ge, Y. et al. Antimicrob. Agents Chemother. 43, 782–788 (1999).
Mosca, D. A. et al. Antimicrob. Agents Chemother. 44, 1803–1808 (2000).
Ghadiri, M. R., Granja, J. R. & Buehler, L. K. Nature 369, 301–304 (1994).
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Ganz, T. Rings of destruction. Nature 412, 392–393 (2001). https://doi.org/10.1038/35086680
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DOI: https://doi.org/10.1038/35086680
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