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Cell cycle

Checking two steps

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When their DNA is damaged, cells temporarily stop multiplying to prevent the build-up of mutations. Two types of delay triggered by ionizing radiation appear to have common molecular starting points.

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Figure 1: Steps involved in the cell-cycle checkpoints that are induced in response to ionizing radiation.

References

  1. Hirao, A. et al. Science 287, 1824–1827 (2000).

    Article  ADS  CAS  Google Scholar 

  2. Kastan, M. B. & Lim, D.-S. Nature Rev. Mol. Cell Biol. 1, 179–186 (2000).

    Article  CAS  Google Scholar 

  3. Falck, J., Mailand, N., Syjuåsen, R. G., Bartek, J. & Lukas, J. Nature 410, 842–847 (2001).

    Article  ADS  CAS  Google Scholar 

  4. Mailand, N. et al. Science 288, 1425–1429 (2000).

    Article  ADS  CAS  Google Scholar 

  5. Matsuoka, S., Huang, M. & Elledge, S. J. Science 282, 1893–1897 (1998).

    Article  ADS  CAS  Google Scholar 

  6. Brown, A. L. et al. Proc. Natl Acad. Sci. USA 96, 3745–3750 (1999).

    Article  ADS  CAS  Google Scholar 

  7. Bell, D. W. et al. Science 286, 2528–2531 (1999).

    Article  CAS  Google Scholar 

  8. Harper, J. W., Adami, G. R., Wei, N., Keyomarsi, K. & Elledge, S. J. Cell 75, 805–816 (1993).

    Article  CAS  Google Scholar 

  9. El-Deiry, W. S. et al. Cell 75, 817–825 (1993).

    Article  CAS  Google Scholar 

  10. Lim, D.-S. et al. Nature 404, 613–617 (2000).

    Article  ADS  CAS  Google Scholar 

  11. Zhao, S. et al. Nature 405, 473–477 (2000).

    Article  ADS  CAS  Google Scholar 

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Correspondence to Michael B. Kastan.

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Kastan, M. Checking two steps. Nature 410, 766–767 (2001). https://doi.org/10.1038/35071218

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