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p27 destruction: Cks1 pulls the trigger

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Recent work has discovered the role of the cyclin-dependent kinase (CDK)-binding protein Cks1 in degrading the CDK inhibitor p27Kip1. This process is essential for DNA replication and is aberrantly enhanced in cancer. Surprisingly, new work indicates that this function of Cks1 is independent of CDKs and links Cks1 with the Skp2 subunit of the SCF ubiquitin ligase.

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Figure 1: Requirements for productive ubiquitinylation of p27.
Figure 2: Deregulation of p27 protein turnover contributes to tumorigenesis.

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Authors and Affiliations

  1. Department of Cell Cycle and Cancer, Institute of Cancer Biology, Danish Cancer Society, Strandboulevarden 49, Copenhagen, DK-2100, Denmark

    Jiri Bartek & Jiri Lukas

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  1. Jiri Bartek
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  2. Jiri Lukas
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Bartek, J., Lukas, J. p27 destruction: Cks1 pulls the trigger. Nat Cell Biol 3, E95–E97 (2001). https://doi.org/10.1038/35070160

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