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S-nitrosylation: spectrum and specificity

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Nitric oxide regulates a broad functional spectrum of proteins by S-nitrosylation. Specificity is conferred by acid–base and hydrophobic motifs that target critical cysteine residues and by protein–protein interactions that confine the signals in space.

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Figure 1: Mechanisms and motifs for S-nitrosylation.

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Hess, D., Matsumoto, A., Nudelman, R. et al. S-nitrosylation: spectrum and specificity. Nat Cell Biol 3, E46–E48 (2001). https://doi.org/10.1038/35055152

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