ATM, the product of the gene that is mutated in the human genetic disorder ataxia telangiectasia (A-T), responds to DNA damage by phosphorylating several key substrates that are involved in both the sensing of damage and the activation of cell-cycle checkpoints. The unexpected activation of ATM kinase in response to insulin supports a more general signalling role for this enzyme.
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References
Yang, D-Q. & Kastan, M. B. Nature Cell Biol. 2, 893–898 ( 2000).
Gatei, M. et al. Nature Genet. 25, 115– 119 (2000).
Cortez, D. Wang, Y. Qin, J. & Elledge, S. J. Science 286, 1162–1166 (1999).
Savitsky, K. et al. Science 268, 1749– 1753 (1995).
Lavin, M. F. & Shiloh, Y. Annu. Rev. Immunol. 15, 177–202 ( 1997).
Fukao, T. et al. Blood 94, 1998–2006 (1999).
Barlow, C. et al. Proc. Natl Acad. Sci. USA 96, 9915– 9919 (1999).
Bar, R. S. et al. N. Engl. J. Med. 298, 1164– 1171 (1978).
Heesom, K. J., Avison, M. B., Diggle, T. A. & Denton, R. M. Biochem. J. 336, 39–48 ( 1998).
Sekulic, A. et al. Cancer Res. 60, 3504– 3513 (2000).
Satney-Mothe, I. et al. J. Biol. Chem. 275, 33836– 33843 (2000).
Blackshear, P. J., Stumpo, D. J., Carballo, E. & Lawrence, J. C. Jr J. Biol. Chem. 272, 31510–31514 (1997).
Oka, A. & Takashima, S. Neurosci. Lett. 252 , 195–198 (1998).
Barlow, C. et al. Proc. Natl Acad. Sci. USA 97, 871– 876 (2000).
Lim, D.S. et al. Proc. Natl Acad. Sci. USA 95, 10146– 10151 (1998).
Watters, D. et al. J. Biol. Chem. 274, 34277– 34282 (1999).
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Lavin, M. An unlikely player joins the ATM signalling network. Nat Cell Biol 2, E215–E216 (2000). https://doi.org/10.1038/35046628
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DOI: https://doi.org/10.1038/35046628
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