Skip to main content
SpringerLink
Log in

Heartfelt crosstalk: desensitization of the GIRK current

  • News & Views
  • Published:

From Nature Cell Biology

View current issue Submit your manuscript

Acetylcholine calms the heartbeat by activating Gi-coupled receptors and G-protein-activated inwardly rectifying potassium (GIRK) channels. It also dampens the GIRK current by reducing PIP2 through Gq-coupled receptors. These two types of receptors seem to be engaged in an intriguingly specific form of crosstalk, which leads to desensitization of the GIRK current.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Desensitization of the acetylcholine response in the sinoatrial pacemaker cell of the heart.
Figure 2: Diagram showing the crosstalk between the M2 and M3 muscarinic acetylcholine receptors in atrial cells.

References

  1. Krupnick, J. G. & Benovic, J. L. Annu. Rev. Pharmacol. Toxicol. 38, 289–319 (1998).

    Article  CAS  Google Scholar 

  2. Chuang, H. H., Yu, M., Jan, Y. N. & Jan, L. Y. Proc. Natl Acad. Sci. USA 95, 11727–11732 (1998).

    Article  CAS  Google Scholar 

  3. Shui, Z., Boyett, M. R., Zang, W. J., Haga, T. & Kameyama, K. J. Physiol. (Lond.) 505, 77–93 (1997).

    Article  CAS  Google Scholar 

  4. Kobrinsky, E., Mirshahi, T., Zhang, H., Jin, T. & Logothetis, D. E. Nature Cell Biol. 2, 507–514 (2000).

    Article  CAS  Google Scholar 

  5. Jalife, J., Hamilton, A. J. & Moe, G. K. Am. J. Physiol. 238, H439–448 (1980).

    CAS  Google Scholar 

  6. Mubagwa, K. & Carmeliet, E. Circ. Res. 53, 740–751 (1983).

    Article  CAS  Google Scholar 

  7. Kurachi, Y., Nakajima, T. & Sugimoto, T. Pflügers Arch. 410, 227–233 (1987).

    Article  CAS  Google Scholar 

  8. Sternweis, P. C. Curr. Opin. Cell Biol. 6, 198–203 (1994).

    Article  CAS  Google Scholar 

  9. Lindorfer, M. A. et al. J. Biol. Chem. 273, 24429–34436 (1998).

    Article  Google Scholar 

  10. Maier, U. et al. J. Biol. Chem. 275, 13746–13754 (2000).

    Article  CAS  Google Scholar 

  11. Zhang, J. H. & Simonds, W. F. J. Neurosci. 20, 1–5 (2000).

    Article  Google Scholar 

  12. Leaney, J. L., Milligan, G. & Tinker, A. J. Biol. Chem. 275, 921–929 (2000).

    Article  CAS  Google Scholar 

  13. Doupnik, C. A., Davidson, N., Lester, H. A. & Kofuji, P. Proc. Natl Acad. Sci. USA 94, 10461–10466 (1997).

    Article  CAS  Google Scholar 

  14. Saitoh, O. et al. J. Biol. Chem. 274, 9899–9904 (1999).

    Article  CAS  Google Scholar 

  15. Velimirovic, B. M., Koyano, K. Nakajima, S. & Nakajima, Y. Proc. Natl Acad. Sci. USA 92, 1590–1594 (1995).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Howard Hughes Medical School and in the Departments of Physiology and Biochemistry, University of California at San Francisco, San Francisco, 94143-0725, California, USA

    Lily Yeh Jan & Yuh Nung Jan

Authors
  1. Lily Yeh Jan
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yuh Nung Jan
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Jan, L., Jan, Y. Heartfelt crosstalk: desensitization of the GIRK current. Nat Cell Biol 2, E165–E167 (2000). https://doi.org/10.1038/35023646

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/35023646

  • Springer Nature Limited

Search

Navigation