There are 'roadblocks' at several points in the signalling pathways that control programmed cell death. When the cell needs to die, these roadblocks must be removed, and a vertebrate protein that removes one such block has now been identified.
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References
Verhagen, A. et al. Cell 102, 43–53 (2000).
Du, C. et al. Cell 102, 33–42 (2000).
Qin, H. et al. Nature 399, 549–557 (1999).
Kumar, S. Cell Death Differ. 6, 1060–1066 (1999).
Ekert, P. G., Silke, J. & Vaux, D. L. Cell Death Differ. 6, 1081– 1086 (1999).
Deveraux, Q. L., Takahashi, R., Salvesen, G. S. & Reed, J. C. Nature 388, 300–304 ( 1997).
Steller, H. Nature Cell Biol. 2, E100–E102 (2000).
Wang, S. L., Hawkins, C. J., Yoo, S. J., Mueller, H. A. J. & Hay, B. A. Cell 98, 453 –463 (1999).
Rothe, M. et al. Cell 83, 1243–1252 (1995).
Brodsky, M. H. et al. Cell 101, 103–113 (2000).
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De Laurenzi, V., Melino, G. The little devil of death. Nature 406, 135–136 (2000). https://doi.org/10.1038/35018190
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DOI: https://doi.org/10.1038/35018190
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