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VHL takes HIF’s breath away

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Abstract

Inactivation of the von Hippel–Lindau (VHL) tumour-suppressor protein (pVHL) is associated with the von Hippel–Lindau cancer syndrome and the majority of kidney cancers. New evidence suggests that pVHL has properties of an F-box protein that targets the α-subunits of hypoxia-inducible factor (HIF)-1 for oxygen-dependent ubiquitination.

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Figure 1: The VCB–Cul2 complex, a close relative of the SCF family of ubiquitin–ligase complexes.
Figure 2: Model for the regulation of HIF-α stability by the VCB–Cul2 ubiquitin–ligase complex.

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  1. the Friedrich Miescher Institute, Maulbeerstrasse 66, CH-4058, Basel, Switzerland

    Wilhelm Krek

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  1. Wilhelm Krek
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Correspondence to Wilhelm Krek.

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Krek, W. VHL takes HIF’s breath away. Nat Cell Biol 2, E121–E123 (2000). https://doi.org/10.1038/35017129

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