Abstract
Most proteins that are secreted or expressed on a cell surface are synthesized on membrane polysomes and enter the endoplasmic reticulum (ER) as unfolded polypeptide chains. A complex series of interactions with resident enzymes and molecular chaperones ensure that these proteins are folded and assembled to achieve their correct tertiary structures before being transported to the Golgi and along the secretory pathway. However, the mechanism by which properly folded molecules are sorted from incompletely or improperly folded proteins and from the resident proteins that guide this process remains unclear.
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References
Hammond, C. & Helenius, A. Curr.Opin.Cell Biol. 7, 523–529 (1995).
Nehls, S. et al. Nature Cell Biol. 2, 288– 295 (2000).
Lodish, H. F., Kong, N., Snider, M. & Strous, G. J. Nature 304, 80–83 (1983).
Wieland, F. T., Gleason, M. L., Serafini, T. A. & Rothman, J. E. Cell 50, 289–300 ( 1987).
Haas, I. G. & Wabl, M. Nature 306, 387–389 (1983).
Hendershot, L., Bole, D., Kohler, G. & Kearney, J. F. J. Cell Biol. 104, 761–767 ( 1987).
Munro, S. & Pelham, H. R. Cell 48, 899–907 (1987).
Lewis, M. J., Sweet, D. J. & Pelham, H. R. Cell 61, 1359– 1363 (1990).
Lippincott-Schwartz, J., Yuan, L. C., Bonifacino, J. S. & Klausner, R. D. Cell 56, 801–813 ( 1989).
Balch, W. E., McCaffery, J. M., Plutner, H. & Farquhar, M. G. Cell 76, 841–852 ( 1994).
Schimmoller, F. et al. EMBO J. 14, 1329–1339 (1995).
Nichols, W. C. et al. Cell 93, 61–70 (1998).
Reddy, P., Sparvoli, A., Fagioli, C., Fassina, G. & Sitia, R. EMBO J. 15, 2077–2085 (1996).
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Hendershot, L. Giving protein traffic the green light. Nat Cell Biol 2, E105–E106 (2000). https://doi.org/10.1038/35014100
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DOI: https://doi.org/10.1038/35014100
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