When making proteins, cells opt for high speed at the cost of large amounts of waste. But the waste-recycling process has a happy side effect — it gives the immune system a head start in its battle against viral invaders.
This is a preview of subscription content, log in via an institution to check access.
References
Schubert, U. et al. Nature 404, 770–774 (2000).
Reits, E. A. J., Vos, J. C., Grommé, M. & Neefjes, J. Nature 404, 774–778 ( 2000).
Yewdell, J. W., Anton, L. C. & Bennink, J. R. J. Immunol. 157, 1823– 1826 (1996).
Boon, T. & Van Pel, A. Immunogenetics 29, 75–79 (1989).
Elliott, T., Bodmer, H. & Townsend, A. Eur. J. Immunol. 26, 1175– 1179 (1996).
Malarkannan, S., Horng, T., Shih, P. P., Schwab, S. & Shastri, N. Immunity 10, 681– 690 (1999).
Mayrand, S. M. & Green, W. R. Immunol. Today 19, 551–556 (1998).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Schild, H., Rammensee, HG. Perfect use of imperfection. Nature 404, 709–710 (2000). https://doi.org/10.1038/35008165
Issue Date:
DOI: https://doi.org/10.1038/35008165
- Springer Nature Limited
This article is cited by
-
Making sense of mass destruction: quantitating MHC class I antigen presentation
Nature Reviews Immunology (2003)