Skip to main content
SpringerLink
Log in

Proteomics

Guilt-by-association goes global

  • News & Views
  • Published:

From Nature

View current issue Submit your manuscript

Clues to the function of a protein can be obtained by seeing whether it interacts with another protein of known function. This principle of guilt-by-association has now been applied to the entire protein complement of yeast.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Levels of gene-function analysis.
Figure 2: Detection of protein associations in yeast using the two-hybrid system.

References

  1. Goffeau, A. et al. Science 274, 546–567 (1996).

    Article  ADS  CAS  Google Scholar 

  2. Fromont-Racine, M. et al. Nature Genet. 16, 277– 282 (1997).

    Article  CAS  Google Scholar 

  3. Mayes, A. E. et al. EMBO J. 18, 4321–4331 (1999).

    Article  CAS  Google Scholar 

  4. Flores, A. et al. Proc. Natl Acad. Sci. USA 96, 7815– 7820 (1999).

    Article  ADS  CAS  Google Scholar 

  5. Uetz, P. et al. Nature 403, 623–627 (2000).

    Article  ADS  CAS  Google Scholar 

  6. http://curatools.curagen.com

  7. Oliver, S. G. et al. Trends Biotechnol. 16, 373– 378 (1998).

    Article  CAS  Google Scholar 

  8. Hoheisel, J. D. Trends Biotechnol. 15, 465–469 (1997).

    Article  CAS  Google Scholar 

  9. Sagliocco, F. et al. Yeast 12, 1519–1534 (1996).

    Article  CAS  Google Scholar 

  10. Shevchenko, A. et al. Proc. Natl Acad. Sci. USA 93, 14440 –14445 (1996).

    Article  ADS  CAS  Google Scholar 

  11. Summerfield, S. G. et al. Int. J. Mass Spectrosc. 188, 1– 2 (1999).

    Article  Google Scholar 

  12. Link, A. J. et al. Nature Biotechnol. 17, 676– 682 (1999).

    Article  CAS  Google Scholar 

  13. Velculescu, V. E. et al. Cell 88, 243–251 (1997).

    Article  CAS  Google Scholar 

  14. Planta, R. J. et al. Yeast 15, 329–350 (1999).

    Article  CAS  Google Scholar 

  15. Teusink, B. et al. Methods Microbiol. 26, 297– 336 (1998).

    Article  CAS  Google Scholar 

  16. Brindle, K. et al. J. Mol. Recog. 10, 182– 187 (1997).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. School of Biological Sciences, University of Manchester, 2.205 Stopford Building, Oxford Road, Manchester, M13 9PT, UK

    Stephen Oliver

Authors
  1. Stephen Oliver
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Stephen Oliver.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Oliver, S. Guilt-by-association goes global. Nature 403, 601–602 (2000). https://doi.org/10.1038/35001165

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/35001165

  • Springer Nature Limited

This article is cited by

Search

Navigation