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Neurobiology

Nogo in nerve regeneration

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A protein long thought to inhibit the growth of regenerating nerve axons has at last been identified and cloned. This discovery could be an important step towards promoting nerve regeneration after stroke or spinal-cord injury.

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Figure 1: The three isoforms of Nogo.
Figure 2: Inhibition of axon regeneration.

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Correspondence to J. L. Goldberg or B. A. Barres.

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Goldberg, J., Barres, B. Nogo in nerve regeneration. Nature 403, 369–370 (2000). https://doi.org/10.1038/35000309

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