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CD95: more than just a death factor?

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Abstract

The CD95 protein delivers crucial signals for lymphocyte death, and may also negatively regulate T-lymphocyte activation by preventing the influx of calcium ions from the cell’s exterior. The block in calcium-ion influx occurs through the activation of acidic sphingomyelinase and the release of ceramide, a metabolite that can also induce cell death.

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Figure 1: Interfering with Ca2+ entry into T lymphocytes.
Figure 2: Possible relationship between cell-death and Ca2+-regulating signals.

Notes

  1. Erratum. Caspases act at aspartate residues within their targets, rather than at cysteine residues as stated.

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Authors and Affiliations

  1. the Centre d’Immunologie INSERM-CNRS de Marseille-Luminy, Case 906, Marseille, Cedex 9, 13288, France

    Anne-Odile Hueber

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  1. Anne-Odile Hueber
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Hueber, AO. CD95: more than just a death factor?. Nat Cell Biol 2, E23–E25 (2000). https://doi.org/10.1038/35000092

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